Ambient Air Pollution Exposure and Fecundability in Women Undergoing In Vitro Fertilization
Sabah M Quraishi1, Paul C Lin2, Kevin S Richter3
1Department of Epidemiology, University of Washington, Seattle, WA.
Environmental Epidemiology (Philadelphia, Pa.)
|June 20, 2019
Summary
Long-term exposure to air pollution may impact in vitro fertilization (IVF) success, particularly for women with diminished ovarian reserve or male infertility. Further research is needed to confirm these findings and explore interventions.
Area of Science:
- Environmental Health
- Reproductive Medicine
- Epidemiology
Background:
- Limited research exists on ambient air pollution's impact on fecundity.
- Susceptible populations for air pollution's adverse reproductive effects remain unidentified.
Purpose of the Study:
- To investigate the association between long-term ambient air pollution exposure and livebirth success in women undergoing in vitro fertilization (IVF).
- To determine if infertility diagnoses modify the relationship between air pollution and IVF outcomes.
Main Methods:
- Study included 7,463 women initiating their first autologous IVF cycle (2012-13).
- Exposure assessment involved estimating annual average fine particulate matter (PM2.5), PM10, and nitrogen dioxide (NO2) at residential addresses.
- Risk ratios were calculated using modified Poisson regression, with effect modification evaluated by infertility diagnosis.
Main Results:
- 36% of participants achieved livebirth.
- A non-significant trend suggested PM2.5 or NO2 exposure was linked to reduced livebirth and increased pregnancy loss.
- Residence near major roadways was associated with decreased livebirth (RR: 0.96).
- Evidence indicated effect modification between air pollutant exposure and diminished ovarian reserve or male infertility diagnoses on livebirth.
Conclusions:
- Overall effects of air pollution on fecundity remain uncertain.
- Synergistic effects between air pollution and diminished ovarian reserve or male infertility diagnoses on livebirth success are suggested.
- Findings highlight potential targets for future research and interventions in reproductive health.
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