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Related Concept Videos

Ureters01:22

Ureters

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The ureters are retroperitoneal tubes located on either side of the vertebral column. They are responsible for transporting urine from each kidney to the urinary bladder. These tubes have thick walls and are approximately 25-30 cm long. Their diameter is around 10 mm at the renal pelvis, gradually narrowing to 1 mm as the ureter obliquely enters the posterior bladder wall through the ureteric orifices. The shape of these orifices is slit-like, which helps to prevent urine backflow toward the...
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Imaging Studies I: Kidney, Ureter, and Bladder Studies01:28

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Kidney, Ureter, and Bladder (KUB) StudiesKidney, Ureter, and Bladder (KUB) studies are standard diagnostic imaging procedures used to assess the anatomy of the urinary system. They are commonly utilized for patients experiencing abdominal pain or urinary symptoms. By using a simple X-ray of the abdomen, KUB studies can reveal structural and pathological abnormalities within the kidneys, ureters, and bladder. These studies are particularly valuable in diagnosing kidney stones, urinary...
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Anatomy of the Genitourinary System I: Kidneys and Ureters01:11

Anatomy of the Genitourinary System I: Kidneys and Ureters

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The upper urinary system comprises two kidneys and two ureters, which are crucial in filtering blood and forming urine.KidneysLocation and Structure:The kidneys are two bean-shaped organs positioned behind the peritoneum on either side of the spine.Kidneys are between the 12th thoracic (T12) and the 3rd lumbar (L3) vertebrae.The position of the liver causes the right kidney to sit slightly lower than the left.Protective Layers:Each kidney is enveloped in a tough, fibrous membrane called the...
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Subviral Agents01:29

Subviral Agents

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Subviral agents are infectious entities that resemble viruses but lack one or more viral components, such as a capsid or essential replication machinery. These agents include viroids, prions, and satellites, each possessing distinct structural and functional characteristics that influence their mode of infection and replication.Viroids are the simplest subviral agents, consisting of circular, single-stranded RNA molecules without a protein coat. They exclusively infect plants, relying entirely...
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Infrared (IR) Spectroscopy: Overview01:09

Infrared (IR) Spectroscopy: Overview

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When electromagnetic radiation passes through a material, atoms or molecules transition from a lower to a higher energy state by absorbing radiation corresponding to the energy difference between the two states. The absorption of infrared (IR) radiation causes transitions between vibrational energy levels in a molecule. Therefore, IR spectroscopy is a useful analytical tool for determining the molecular structure of molecules.
Different compounds display unique properties due to their...
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Air-entraining Agents01:27

Air-entraining Agents

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Air-entraining agents improve the durability and workability of concrete in climates with frequent freezing and thawing. These agents prevent cracks by introducing small air bubbles into the mix, creating spaces accommodating water expansion when temperatures drop. The air-entraining agents lower the surface tension of water, forming stable, small air bubbles. This method is more effective than having accidental large voids, as the intentional, smaller, and evenly distributed air voids improve...
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Intraoperative ureter visualization using a near-infrared imaging agent.

Richard W Farnam1, Richard G Arms2, Alwin H Klaassen3

  • 1Texas Urogynecology and Laser Surgery Center, Las Palmas Medical Center, El Paso, Texas, United States.

Journal of Biomedical Optics
|June 20, 2019
PubMed
Summary

The novel fluorescent imaging agent IS-001 is safe and effective for enhancing ureter visualization during minimally invasive hysterectomy. This first-in-human study demonstrates its potential for improved surgical safety and outcomes.

Keywords:
hysterectomynear-infraredrobotic-assisted minimally invasive surgeryureter imaging

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Area of Science:

  • Surgical innovation
  • Medical imaging
  • Pharmacology

Background:

  • Minimally invasive hysterectomy requires precise identification of anatomical structures.
  • Ureter visualization can be challenging during gynecological surgeries.
  • Current visualization techniques may have limitations in real-time intraoperative guidance.

Purpose of the Study:

  • To evaluate the clinical safety and efficacy of the fluorescent imaging agent IS-001.
  • To assess the potential of IS-001 for real-time ureter visualization during hysterectomy.
  • To determine the feasibility of using IS-001 with near-infrared (NIR) imaging technology.

Main Methods:

  • A first-in-human clinical study was conducted.
  • Subjects received the fluorescent imaging agent IS-001.
  • Ureter visualization was assessed using a clinically approved NIR-sensitive endoscope during hysterectomy procedures.

Main Results:

  • The imaging agent IS-001 was well tolerated in all subjects.
  • IS-001 demonstrated enhanced ureter visualization capabilities.
  • The agent is renally excreted, indicating a predictable pharmacokinetic profile.
  • Preliminary results suggest safety and efficacy for surgical application.

Conclusions:

  • The fluorescent imaging agent IS-001 is safe and well-tolerated.
  • IS-001 facilitates enhanced ureter visualization during minimally invasive hysterectomy.
  • This agent shows significant potential for improving surgical safety and outcomes in gynecological procedures.