Fe₃O₄-based nanotheranostics for magnetic resonance imaging-synergized multifunctional cancer management

Iron oxide (Fe₃O₄)-based theranostic agents show great promise toward advancing personalized nanomedicine due to their extraordinary physicochemical and biological properties. This original review aims to highlight and summarize the most recent progress of Fe₃O₄, starting with the synthesis and surface modification of superparamagnetic iron oxide nanoparticles (NPs). Desirable features of Fe₃O₄ are the initial focus, followed by a review of their theranostic applications including sensitive MRI, multimodal imaging and MRI-guided cancer therapy. Finally, potential nanotoxicity, regulatory and clinical translation barriers are addressed to outline future perspectives on Fe₃O₄ NP-based multifunctional theranostic platforms. It is strongly believed that in the near future, Fe₃O₄ NPs will open new routes with regard to cancer management.