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Updated: Jan 23, 2026
Perturbations of Circulating miRNAs in Irritable Bowel Syndrome Detected Using a Multiplexed High-throughput Gene Expression Platform
Published on: November 30, 2016
[CAPSUMEN IN THE TREATMENT OF IRRITABLE BOWEL SYNDROME]
G Solovyova1, K Kvacheniuk2, S Vlasyuk3
11Bogomolets National Medical University, Kyiv; 3Мedical Centre "Universal Clinic "Oberig", Kyiv; 4Kyiv city consultative and diagnostic Centre, Kyiv, Ukraine.
Capsumen significantly reduced abdominal pain and improved symptoms like diarrhea and constipation in Irritable Bowel Syndrome (IBS) patients within two weeks. This treatment also normalized gut microflora and enhanced overall quality of life.
Area of Science:
- Gastroenterology
- Pharmacology
- Microbiology
Background:
- Irritable bowel syndrome (IBS) is a prevalent functional gastrointestinal disorder affecting 5-20% of the global population.
- IBS presents with diverse symptoms including diarrhea, constipation, abdominal pain, and bloating, significantly impacting patient quality of life.
- Current management strategies for IBS often yield suboptimal results, necessitating novel therapeutic approaches.
Purpose of the Study:
- To evaluate the efficacy of capsumen in managing symptoms of Irritable Bowel Syndrome (IBS).
- To compare the clinical outcomes of IBS patients treated with capsumen versus those without capsumen.
- To assess capsumen's impact on abdominal pain, bowel habits, meteorism, intestinal microflora, and psychological well-being in IBS patients.
Main Methods:
- A cross-sectional study involving 112 adult patients diagnosed with IBS (diarrhea or constipation predominant).
- Patients were categorized into four groups: IBS with diarrhea (with/without capsumen) and IBS with constipation (with/without capsumen).
- Clinical symptoms, including abdominal pain, meteorism, diarrhea, constipation, and quality of life indicators, were monitored over a two-week period.
Main Results:
- Capsumen demonstrated a statistically significant reduction in abdominal pain for both IBS-diarrhea and IBS-constipation patients by the second week.
- Rapid improvement in meteorism was observed in patients receiving capsumen.
- Capsumen treatment led to the relief of diarrhea and constipation symptoms within two weeks, normalization of intestinal microflora, and improved quality of life by reducing anxiety and depression.
Conclusions:
- Capsumen is an effective therapeutic agent for alleviating key symptoms of Irritable Bowel Syndrome (IBS).
- The study highlights capsumen's ability to improve gut microbiota balance and enhance the psychological well-being of IBS patients.
- Capsumen offers a promising treatment option for improving the clinical course and quality of life for individuals suffering from IBS.
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