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RISK FACTORS AND COMORBIDITY IN DIFFERENT TYPES OF FUNCTIONAL DYSPEPSIA: RETROSPECTIVE COHORT ANALYSIS.

G Solovyova1, T Alianova2, A Taran2

  • 11Bogomolets National Medical University, Kyiv, Ukraine; 2Medical Centre "Oberig" clinic, Kyiv, Ukraine.

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Summary
This summary is machine-generated.

Functional dyspepsia (FD) is linked to unemployment and sleep disorders, not smoking or alcohol. Irritable bowel syndrome (IBS) and depression are more common in postprandial distress syndrome (PDS) than epigastric pain syndrome (EPS).

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Area of Science:

  • Gastroenterology
  • Internal Medicine
  • Psychiatry

Background:

  • Functional dyspepsia (FD) and irritable bowel syndrome (IBS) frequently overlap, but previous research often used outdated criteria and lacked differential analysis between FD subtypes.
  • Understanding risk factors and comorbidities for different types of FD is crucial for accurate diagnosis and treatment.

Purpose of the Study:

  • To assess risk factors and comorbid conditions associated with FD.
  • To compare the prevalence of these factors in FD patients versus a control group.
  • To differentiate risk factors and comorbidities between postprandial distress syndrome (PDS) and epigastric pain syndrome (EPS).

Main Methods:

  • Retrospective database analysis of patients with newly diagnosed FD and a control group.
  • Collection of demographic, lifestyle, and comorbidity data from medical files.
  • Statistical analysis to compare risk factors and comorbidity frequencies between FD and control groups, and between PDS and EPS subtypes.

Main Results:

  • Unemployment and sleep disorders were identified as significant risk factors for FD.
  • Smoking, alcohol consumption, and family status were not associated with increased FD risk.
  • Gastroesophageal reflux disease (GERD), IBS, chronic gastritis/duodenitis, anxiety, and depression were more frequent in FD patients.
  • IBS and depression were significantly more prevalent in the PDS group compared to the EPS group.
  • No significant differences in risk factors were found between PDS and EPS subtypes.

Conclusions:

  • FD is associated with specific lifestyle and psychological factors, highlighting the importance of considering these in patient evaluation.
  • Certain comorbidities, particularly IBS and depression, show differential prevalence between FD subtypes, suggesting distinct underlying mechanisms.
  • Further research is needed to explore the specific pathways linking unemployment and sleep disorders to FD.