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Related Concept Videos

Synthetic Biology02:55

Synthetic Biology

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Synthetic biology is an interdisciplinary science that involves using principles from disciplines such as engineering, molecular biology, cell biology, and systems biology. It involves remodeling existing organisms from nature or constructing completely new synthetic organisms for applications such as protein or enzyme production, bioremediation, value-added macromolecule production, and the addition of desirable traits to crops, to name a few.
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Therapeutic Index01:13

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The therapeutic index of a drug is a key parameter in pharmacology that quantifies the relative safety of a drug by calculating the ratio between the dose that causes toxicity in half the population (50%) to the dose that proves to be effective for half the population (50%). It provides a spectrum of doses for a particular drug ranging from effective to potentially toxic. To illustrate, consider an anticoagulant agent like warfarin. It possesses a narrow window within its therapeutic index to...
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The Tree of Life - Bacteria, Archaea, Eukaryotes02:40

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The “tree of life” describes the evolution of life and the evolutionary relationships between organisms. The root of the tree is the common ancestor to all life on Earth. All other species radiate from this point, much like the branches of a tree. The numerous tips of these branches on the tree of life represent every living, or extant, species. Extinct species, which are species that no longer exist, can be found towards the center of the tree. Currently, these organisms, both...
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Microorganisms in Medicine and Therapeutics01:29

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Microorganisms play a fundamental role in vaccine development, gene therapy, and therapeutic production. Their biological properties are harnessed to advance medicine and public health. Beyond immunization, microorganisms contribute to gut health, antibiotic synthesis, and genetic disease treatment.Live Attenuated and Inactivated VaccinesLive attenuated vaccines, such as the measles, mumps, and rubella (MMR) vaccine, utilize weakened forms of pathogens to closely resemble natural infections.
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Engineering Adherent Bacteria by Creating a Single Synthetic Curli Operon
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Synthetic Bacteria for Therapeutics.

Phuong Vo1, Hyang-Mi Lee1, Dokyun Na1

  • 1School of Integrative Engineering, Chung-Ang University, Seoul 06974, Republic of Korea.

Journal of Microbiology and Biotechnology
|June 21, 2019
PubMed
Summary

Synthetic biology uses engineered bacteria for advanced diagnostics and therapeutics. These living medicines offer new ways to treat diseases by sensing and responding to the body.

Keywords:
Synthetic biologycancerdisease diagnosisliving therapeuticsmetabolic diseasessynthetic bacterium-based therapies

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Area of Science:

  • Synthetic biology
  • Genetic engineering
  • Microbial biotechnology

Background:

  • Synthetic biology enables the creation of programmed biological systems for diverse applications.
  • Engineered bacteria offer advanced diagnostic and therapeutic capabilities surpassing traditional methods.
  • These systems leverage bacterial sensing and response to internal biological signals.

Purpose of the Study:

  • To review designed synthetic bacterial systems as living therapeutics.
  • To highlight their application in diagnosing and treating various diseases.
  • To discuss the safety and robustness of these genetically modified organisms in vivo.

Main Methods:

  • Review of current literature on synthetic biology applications in medicine.
  • Analysis of engineered bacterial systems for diagnostic and therapeutic functions.
  • Evaluation of safety and robustness studies for in vivo applications.

Main Results:

  • Synthetic bacteria demonstrate potential for superior disease diagnosis and treatment.
  • Engineered microbes can act as 'living therapeutics' by responding to disease-specific signals.
  • Research is exploring the safety and efficacy of these systems within the human body.

Conclusions:

  • Synthetic bacterial systems represent a promising frontier in medical diagnostics and therapeutics.
  • Further research is needed to ensure the safety and efficacy of these living medicines.
  • The integration of synthetic biology offers novel strategies for personalized medicine.