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Lycopene and cognitive function.

Kristi M Crowe-White1, Tinsley A Phillips1, Amy C Ellis1

  • 1Department of Human Nutrition, University of Alabama, Box 870311, Tuscaloosa, AL 35487, USA.

Journal of Nutritional Science
|June 21, 2019
PubMed
Summary
This summary is machine-generated.

Lycopene, an antioxidant, may support cognitive function and longevity. More research is needed to confirm lycopene

Keywords:
AD, Alzheimer's diseaseAlzheimer's diseaseCognitionCognitive functionDementiaICD, International Statistical Classification of Diseases and Related Health ProblemsLycopeneMMSE, Mini-Mental State ExaminationROS, reactive oxygen species

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Area of Science:

  • Nutritional Neuroscience
  • Gerontology
  • Oxidative Stress Research

Background:

  • Aging is associated with cognitive decline, driven by oxidative stress and inflammation.
  • Lycopene, a carotenoid, possesses antioxidant and anti-inflammatory properties.
  • Understanding lycopene's role in cognitive health is crucial for aging populations.

Purpose of the Study:

  • To review existing evidence on the relationship between lycopene and cognitive function.
  • To assess lycopene's potential protective effects against dementia development and progression.
  • To identify research gaps concerning lycopene and cognitive longevity.

Main Methods:

  • Systematic literature search of cross-sectional and longitudinal studies.
  • Inclusion of studies examining circulating or dietary lycopene.
  • Analysis of outcomes related to maintained cognition, dementia development, and mortality.

Main Results:

  • Three out of four studies showed a positive association between lycopene and maintained cognitive function.
  • No significant relationship was found between lycopene and dementia development in two studies.
  • One study indicated lower lycopene levels correlated with higher Alzheimer's disease mortality.

Conclusions:

  • Current evidence is insufficient to establish a definitive protective role for lycopene in cognitive function or dementia.
  • Low circulating lycopene is linked to all-cause mortality, warranting further investigation.
  • Future research should explore lycopene's impact on cognitive longevity and dementia-related mortality.