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Published on: January 31, 2011
Isolation, structural elucidation and in vitro hepatoprotective activity of flavonoids from Glycyrrhiza uralensis
Ming Cheng1,2, Liqin Ding2, Hongfeng Kan3
1School of Chinese Materia Medica, Tianjin University of Traditional Chinese Medicine, No. 312 Anshanxi Road, Nankai District, Tianjin, 300193, China.
Abstract:
Two new flavonoid glycosides, 2',4'-dihydroxydihydrochalcone-4-O-β-D-glucopyranoside (1) and medicarpin-3-O-β-D-apiofuranosyl (1 → 2)-β-D-glucopyranoside (2), together with 34 known flavonoids were isolated from the 75% EtOH extract of the dried roots of Glycyrrhiza uralensis Fisch. Their structures were elucidated on the basis of spectroscopic analyses. The flavonoids were classified into ten sub-types, namely, dihydrochalcone (1), pterocarpans (2-4), flavones (5-6), flavanones (7-11), chalcones (12-15), retro-chalcones (16-18), isoflavans (19-21), isoflavones (22-28), 3-arylcoumarins (29-30), and coumestans (31-36). The isolated flavonoids were evaluated for in vitro hepatoprotective activity against D-galactosamine-induced toxicity in human hepatoma HepG2 cells.
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