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Patterned plasmonic gradient for high-precision biosensing using a smartphone reader.

Jie Bian1, Xing Xing1, Shuang Zhou1

  • 1College of Engineering and Applied Sciences, National Laboratory of Solid State Microstructures, Collaborative Innovation Center of Advanced Microstructures and Jiangsu Key Laboratory of Artificial Functional Materials, MOE Key Laboratory of Intelligent Optical Sensing and Manipulation, Nanjing University, Nanjing, 210093, P.R. China. luzhenda@nju.edu.cn zwh@nju.edu.cn.

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|June 21, 2019
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Summary
This summary is machine-generated.

A novel metasurface-inspired biosensor, the patterned plasmonic gradient (PPG), achieves high-precision molecular detection using smartphone capabilities. This advancement offers accurate diagnostics in remote areas lacking professional equipment.

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Area of Science:

  • Biomedical Engineering
  • Nanotechnology
  • Analytical Chemistry

Background:

  • Smartphone biosensors are crucial for remote diagnostics but often lack the precision of conventional methods due to detector limitations.
  • Existing smartphone biosensors struggle to meet the performance specifications of laboratory-grade equipment.

Purpose of the Study:

  • To develop a smartphone-compatible biosensor with high sensitivity and accuracy for remote diagnostic applications.
  • To overcome the limitations of consumer-grade smartphone detectors in biosensing.

Main Methods:

  • Introduced a metasurface-inspired biosensor: patterned plasmonic gradient (PPG).
  • PPG transduces local refractive index changes into 2D patterns.
  • Utilized smartphone imaging and computational power for high-precision detection (Δn < 0.001).

Main Results:

  • The PPG biosensor demonstrated high sensitivity, detecting submonolayer molecules.
  • Real-time monitoring of biotin-streptavidin conjugation (15 nM) was achieved.
  • The biosensor operates with high precision and a large dynamic range.

Conclusions:

  • The PPG biosensor offers a high-performance, smartphone-compatible solution for sensitive molecular detection.
  • This technology enhances diagnostic capabilities in resource-limited or remote settings.
  • The PPG biosensor bridges the gap between portable and professional diagnostic tools.