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Updated: Jan 23, 2026

Isolation and Profiling of MicroRNA-containing Exosomes from Human Bile
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Exosomal microRNA and stroke: A review

Abdolreza Ghoreishy1, Alireza Khosravi2, Amir Ghaemmaghami3

  • 1Department of Neurology, School of Medicine, Zanjan University of Medical Sciences, Zanjan, Iran.

Journal of Cellular Biochemistry
|June 21, 2019
PubMed

Insights

Exosomes carry microRNAs (miRNAs) that play a key role in stroke development. Understanding these exosomal miRNAs could lead to new stroke therapies and diagnostic biomarkers.

Area of Science:

  • Neuroscience
  • Molecular Biology
  • Biochemistry

Background:

  • Stroke, caused by brain blood vessel rupture or occlusion, is a leading global cause of death and disability.
  • Current therapeutic strategies for stroke remain limited, with many preclinical neuroprotective agents failing in clinical trials.
  • MicroRNAs (miRNAs) are small noncoding RNAs regulating cellular pathways, and their dysregulation is implicated in stroke initiation and progression.

Purpose of the Study:

  • To review the role of exosomal microRNAs (miRNAs) in the pathogenesis of stroke.
  • To highlight the potential of exosomal miRNAs as therapeutic targets and noninvasive biomarkers for stroke.

Main Methods:

  • Literature review of studies investigating exosomal miRNAs in stroke.
  • Analysis of the mechanisms by which exosomal miRNAs influence stroke pathology.
  • Evaluation of exosomal miRNAs as diagnostic and prognostic indicators in stroke.

Main Results:

  • Exosomes act as crucial nano-carriers, transferring miRNAs that significantly contribute to stroke pathogenesis.
  • Specific exosomal miRNAs have been identified as key players in the molecular and cellular events underlying stroke.
  • Exosomal miRNAs demonstrate potential as noninvasive biomarkers for stroke diagnosis and monitoring treatment response.

Conclusions:

  • Exosomal miRNAs are integral to stroke pathogenesis, offering novel insights into disease mechanisms.
  • Targeting exosomal miRNAs presents a promising avenue for developing innovative stroke therapeutics.
  • Exosomal miRNAs hold significant potential for noninvasive diagnosis and personalized therapy monitoring in stroke patients.
Keywords:
exosomemicroRNAstroke

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