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Updated: Jan 23, 2026
07:55
Establishment of a Primary Culture of Patient-derived Soft Tissue Sarcoma
Published on: April 11, 2018
14.9K
Alveolar soft-part sarcoma: Case demonstrating principles for uncommon vascular lesions
Maria Leszczynska1, Diana S Jodeh2, Damon Reed3
1Department of General Pediatrics, Johns Hopkins All Children's Hospital, St Petersburg, Florida, USA.
Summary
Alveolar soft-part sarcoma (ASPS) can mimic benign vascular tumors. This case highlights the importance of considering rare diagnoses like ASPS in pediatric tongue masses, even when initial imaging suggests a hemangioma.
Area of Science:
- Pediatric Oncology
- Vascular Anomalies
- Diagnostic Imaging
Background:
- Alveolar soft-part sarcoma (ASPS) is a rare malignancy.
- ASPS can present clinically similar to benign vascular tumors.
- Early recognition is crucial for appropriate management.
Observation:
- A 6-year-old boy with autism spectrum disorder presented with a tongue mass.
- Initial imaging (CT scan) suggested a hemangioma.
- Physical examination revealed a firm, high-flow dorsal tongue lesion.
Findings:
- Excisional biopsy confirmed the tongue mass as alveolar soft-part sarcoma (ASPS).
- Pathologic characteristics were definitive for ASPS diagnosis.
- This case underscores the challenges in differentiating ASPS from vascular malformations.
Implications:
- Vascular anomalies clinics are vital for diagnosing complex cases.
- Advanced imaging and biopsy may be necessary for definitive diagnosis.
- Increased awareness of ASPS presentation is important for clinicians treating pediatric patients.
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