Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Antisocial Personality Disorder

Antisocial Personality Disorder

Antisocial personality disorder is a chronic mental health condition characterized by persistent patterns of disregard for the rights and well-being of others. Individuals with antisocial personality disorder exhibit behaviors that include deceitfulness, impulsivity, irresponsibility, aggression, and a profound lack of empathy. These traits often manifest early in life and persist into adulthood, leading to significant personal, social, and legal consequences.
Behavioral Characteristics and...

Borderline Personality Disorder

Borderline Personality Disorder

Borderline Personality Disorder is a complex and multifaceted mental health condition characterized by pervasive instability in interpersonal relationships, self-image, emotions, and impulse control. This instability manifests in extreme emotional reactions, fear of abandonment, and self-destructive behaviors. The disorder significantly impacts daily functioning, often leading to distress in both personal and professional domains.
Genetic and Environmental Contributions
Borderline Personality...

Personality Disorders: Paranoid and Schizoid

Personality Disorders: Paranoid and Schizoid

Personality disorders represent enduring cognition, affect, and behavior patterns that significantly deviate from societal norms. These maladaptive traits often lead to difficulties in various domains, including interpersonal relationships, occupational settings, and overall psychological well-being. Paranoid personality disorder and schizoid personality disorder are two distinct conditions marked by odd or eccentric behavior.
Paranoid Personality Disorder
Paranoid personality disorder is...

Personality Disorders: Schizotypal and Histrionic

Personality Disorders: Schizotypal and Histrionic

Schizotypal personality disorder and histrionic personality disorder are two distinct psychological conditions classified under personality disorders, each characterized by unique behavioral patterns and social difficulties. Both disorders significantly affect interpersonal relationships and emotional well-being, leading to social isolation and frustration.
Schizotypal Personality Disorder: Eccentric Behavior and Social Withdrawal
Schizotypal personality disorder is marked by odd or eccentric...

Relationship Formation

Relationship Formation

What do you think is the single most influential factor in determining with whom you become friends and whom you form romantic relationships? You might be surprised to learn that the answer is simple: the people with whom you have the most contact. This most important factor is proximity. You are more likely to be friends with people you have regular contact with. For example, there are decades of research that shows that you are more likely to become friends with people who live in your dorm,...

Personality Disorders: Narcissistic and Avoidant

Personality Disorders: Narcissistic and Avoidant

Narcissistic and avoidant personality traits represent two contrasting patterns of behavior that significantly influence social interactions and self-perception. While individuals with narcissistic disorder seek admiration and validation, individuals with avoidant personality disorder withdraw due to fear of judgment.
Characteristics of Narcissistic Personality Disorder
Narcissistic individuals exhibit an inflated sense of self-importance and an excessive need for admiration. They are often...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Association between anxious depression and clinical outcomes in subjects with treatment-resistant depression: a comparative effectiveness research trial for antidepressant incomplete and non-responders with treatment-resistant depression (ASCERTAIN-TRD).

International clinical psychopharmacology·2026

Same author

Functional dysconnectivity in breast cancer patients undergoing hormone therapy.

Journal of clinical and experimental neuropsychology·2026

Same author

Patient treatment preference as a predictor of clinical outcomes in subjects with treatment-resistant depression: a comparative effectiveness research trial for antidepressant incomplete and nonresponders with treatment-resistant depression (ASCERTAIN-TRD).

International clinical psychopharmacology·2026

Same author

Comparative Effectiveness Research Trial for Antidepressant Incomplete and Nonresponders With Treatment Resistant Depression (ASCERTAIN-TRD): Effect of Aripiprazole or Repetitive Transcranial Magnetic Stimulation Augmentation Versus Switching to the Antidepressant Venlafaxine on Quality of Life.

The Journal of clinical psychiatry·2025

Same author

Effect of augmentation with aripiprazole or augmentation with repetitive transcranial magnetic stimulation versus switching to the antidepressant venlafaxine extended release/duloxetine on cognition: A comparative effectiveness research trial for antidepressant incomplete and non-responders with treatment-resistant depression (ASCERTAIN-TRD).

Journal of affective disorders·2025

Same author

The associations between well-being and Cloninger's personality dimensions in a Korean community sample.

PeerJ·2024

Search research articles

Related Experiment Video

Updated: Jan 23, 2026

Author Spotlight: Therapeutic Benefit of Closed-Loop Deep Brain Stimulation in Depression Treatment

Author Spotlight: Therapeutic Benefit of Closed-Loop Deep Brain Stimulation in Depression Treatment

Published on: July 7, 2023

Personality disorders and physical comorbidities: a complex relationship.

Mehmet E Dokucu¹, C Robert Cloninger²

¹Department of Psychiatry & Behavioral Sciences, Northwestern University Feinberg School of Medicine, Chicago, Illinois.

Current Opinion in Psychiatry

|June 21, 2019

Summary

Patients with personality disorders often experience poor physical health. This highlights the need to integrate mental and physical health care, challenging the traditional mind-body separation in medicine.

More Related Videos

Use of a Psychophysiological Script-driven Imagery Experiment to Study Trauma-related Dissociation in Borderline Personality Disorder

Use of a Psychophysiological Script-driven Imagery Experiment to Study Trauma-related Dissociation in Borderline Personality Disorder

Published on: March 8, 2018

Mapping the Structure-Function Relationships of Disordered Oncogenic Transcription Factors Using Transcriptomic Analysis

Mapping the Structure-Function Relationships of Disordered Oncogenic Transcription Factors Using Transcriptomic Analysis

Published on: June 27, 2020

Related Experiment Videos

Last Updated: Jan 23, 2026

Author Spotlight: Therapeutic Benefit of Closed-Loop Deep Brain Stimulation in Depression Treatment

Author Spotlight: Therapeutic Benefit of Closed-Loop Deep Brain Stimulation in Depression Treatment

Published on: July 7, 2023

Use of a Psychophysiological Script-driven Imagery Experiment to Study Trauma-related Dissociation in Borderline Personality Disorder

Use of a Psychophysiological Script-driven Imagery Experiment to Study Trauma-related Dissociation in Borderline Personality Disorder

Published on: March 8, 2018

Mapping the Structure-Function Relationships of Disordered Oncogenic Transcription Factors Using Transcriptomic Analysis

Mapping the Structure-Function Relationships of Disordered Oncogenic Transcription Factors Using Transcriptomic Analysis

Published on: June 27, 2020

Area of Science:

Medical research
Psychiatry
General Medicine

Background:

Clinicians may label unexplained patient symptoms as 'psychogenic'.
This approach overlooks the significant link between personality disorders and physical health issues.

Purpose of the Study:

To review recent literature on the comorbidity of personality disorders and nonpsychiatric medical conditions.
To challenge the traditional mind-body dichotomy in medical practice.

Main Methods:

Review of recent scientific reports and studies.
Analysis of cross-sectional, community-based, and longitudinal data.

Main Results:

A strong association exists between personality disorders and poor health outcomes.
Longitudinal studies confirm that personality disorders predict future health deterioration.
The severity of any personality disorder is linked to worse and worsening health.

Conclusions:

Personality disorders are linked to a wide spectrum of physical, mental, and social disorders.
Focusing on self-regulation features of personality disorders can improve health promotion and disease prevention.
Integrating this understanding can help alleviate the burden of chronic diseases.