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Examining Changes in HRV and Emotion Following Artmaking with Three Different Art Materials
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When medicine transforms art.

Sara Belga1, Clayton MacDonald2, Dima Kabbani1

  • 1Division of Infectious Diseases, Department of Medicine, University of Alberta, Edmonton, Alberta, Canada.

Transplant Infectious Disease : an Official Journal of the Transplantation Society
|June 21, 2019
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Summary
This summary is machine-generated.

A patient experienced visual disturbances, including altered color perception, while taking voriconazole for a fungal infection after a pancreas transplant. Switching to fluconazole resolved these visual side effects.

Keywords:
art paintingcoccidioidomycosisvisual disturbancesvoriconazole

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Area of Science:

  • Medical Mycology
  • Transplant Surgery
  • Ophthalmology

Background:

  • A 40-year-old female with type 1 diabetes mellitus and a history of pancreas transplantation presented with graft rejection.
  • Immunosuppression was increased, prompting empirical treatment with voriconazole for suspected invasive pulmonary aspergillosis.

Observation:

  • An incidental 1.1 cm right lower lobe pulmonary cavity was detected during the patient's workup.
  • The patient, a professional painter, reported significant changes in her color perception, affecting her work.

Findings:

  • The patient was ultimately diagnosed with pulmonary coccidioidomycosis.
  • Visual disturbances, including dyschromatopsia, resolved upon discontinuation of voriconazole and initiation of fluconazole therapy.

Implications:

  • This case highlights voriconazole-induced visual disturbances, such as photopsias and dyschromatopsias, affecting 20-30% of patients.
  • The findings underscore the importance of considering drug-induced visual changes in transplant patients, particularly those with altered color perception.
  • This case illustrates the potential impact of voriconazole on spectral sensitivity and color vision, necessitating careful monitoring in susceptible individuals.