Related Experiment Video
Updated: Feb 28, 2026
10:03
Bioluminescent Monitoring of Graft Survival in an Adoptive Transfer Model of Autoimmune Diabetes in Mice
Published on: November 18, 2022
2.3K
Diabetes Mellitus is a Risk Factor for Developing CMV Retinitis in Solid Organ Transplant Recipients: A Case-control
Dilpreet K Bharaj1, Shanil Dhanji2, Elena Gurung2
1Faculty of Medicine, University of British Columbia, Vancouver, British Columbia, Canada.
Open Forum Infectious Diseases
|February 27, 2026
Summary
Cytomegalovirus retinitis (CMVR) is a rare complication in solid organ transplant (SOT) recipients. Diabetes mellitus significantly increases the risk of developing CMVR after SOT.
Area of Science:
- Ophthalmology
- Transplant Surgery
- Infectious Diseases
Background:
- Improved long-term survival in solid organ transplant (SOT) recipients may be increasing cytomegalovirus retinitis (CMVR) incidence.
- The epidemiology of CMVR post-SOT requires further elucidation.
- This study investigates CMVR incidence and risk factors in SOT recipients.
Purpose of the Study:
- Determine the incidence of CMVR in SOT recipients.
- Identify risk factors associated with CMVR development post-SOT.
- Evaluate the association between diabetes mellitus and CMVR risk.
Main Methods:
- A case-control study with a 1:4 ratio was conducted from January 2012 to March 2024.
- Cases were SOT recipients diagnosed with CMVR; controls were matched by organ, year, and center.
- Conditional logistic regression models were used for univariable and multivariable analyses.
Main Results:
- The incidence of CMVR was 5.3 per 10,000 person-years among 5877 SOT recipients.
- CMVR cases were older and more likely to have diabetes mellitus (DM) and CMV DNAemia compared to controls.
- Diabetes mellitus (DM) was independently associated with increased odds of CMVR (OR 16.5).
Conclusions:
- CMVR is a rare, late-onset complication following SOT.
- Diabetes mellitus is a significant independent risk factor for CMVR in SOT recipients.
- Further research into managing CMVR risk in diabetic SOT patients is warranted.
Related Concept Videos
01:22Diabetes Mellitus: Type 2 and Gestational
5.2K
Type 2 diabetes, characterized by insulin resistance, arises when the insulin receptors on cells lose responsiveness to insulin, diminishing the cell's capacity to take up glucose, resulting in elevated blood glucose levels. To receive a diagnosis of Type 2 diabetes, a series of blood glucose tests are necessary to assess whether the blood glucose falls within normal parameters. If the result is out of the normal range, a patient may be diagnosed as prediabetic or diabetic, depending on the...
5.2K
01:28Kidney Transplant I: Introduction
586
A kidney transplant is a surgical approach that involves replacing a non-functioning kidney with a healthy one from a donor. This procedure is often a treatment option for end-stage renal disease (ESRD) patients. The method requires careful recipient selection, including evaluating various medical and psychosocial factors. These criteria vary between transplant centers but generally include assessments of the patient's overall health, adherence to medical recommendations, and lifestyle...
586
01:22Diabetes Mellitus: Overview and Type I Subtype
5.7K
Diabetes mellitus is a chronic metabolic disorder characterized by high blood glucose levels due to inadequate insulin production, insulin resistance, or both. The condition affects millions worldwide and can significantly impact their health and quality of life.
Type 1 diabetes is an autoimmune disease in which the immune system mistakenly attacks and destroys the insulin-producing beta cells in the pancreas. As a result, the body is unable to produce sufficient insulin, and individuals with...
Type 1 diabetes is an autoimmune disease in which the immune system mistakenly attacks and destroys the insulin-producing beta cells in the pancreas. As a result, the body is unable to produce sufficient insulin, and individuals with...
5.7K
01:20Pathophysiology of Diabetes
3.9K
Diabetes mellitus is a chronic metabolic disorder characterized by hyperglycemia. The four categories of diabetes are type 1 diabetes, type 2 diabetes, other specific types of diabetes, and gestational diabetes.
Type 1 diabetes is characterized by autoimmune-mediated destruction of pancreatic β cells, with environmental factors potentially triggering this process in genetically susceptible individuals. Despite many not having a family history, certain genes increase susceptibility,...
Type 1 diabetes is characterized by autoimmune-mediated destruction of pancreatic β cells, with environmental factors potentially triggering this process in genetically susceptible individuals. Despite many not having a family history, certain genes increase susceptibility,...
3.9K
01:15Diabetes: Symptoms, Diagnosis, and Complications
2.5K
For most patients, experiencing several weeks of polyuria, polydipsia, fatigue, and significant weight loss may indicate the presence of diabetes. Furthermore, adults displaying the phenotypic appearance of type 2 diabetes (particularly those who are obese and not initially insulin-requiring), may have islet cell autoantibodies, suggesting autoimmune-mediated β cell destruction and a diagnosis of latent autoimmune diabetes of adults (LADA). The categorization of glucose homeostasis is...
2.5K
01:19Psychoneuroimmunology: Diabetes and Cancer
547
Chronic stress has been linked to both the onset and progression of serious health conditions, including Type 2 diabetes and cancer. Type 2 diabetes, a widespread chronic illness, is closely associated with obesity and insulin resistance, both of which often worsen under stress. Studies indicate that men experiencing high levels of chronic stress face a 45% higher risk of developing diabetes compared to those with minimal stress. Stress triggers physiological responses that elevate blood...
547