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Published on: May 17, 2024
Correlations between embryo morphokinetic development and maternal age: Results from an intracytoplasmic sperm
Azita Faramarzi1,2, Mohammad Ali Khalili2,3, Esmat Mangoli2
1Fertility and Infertility Research Center, Health Technology Institute, Kermanshah University of Medical Sciences, Kermanshah, Iran.
Maternal age impacts embryo development. Advanced maternal age is linked to specific abnormal embryo cleavage patterns, suggesting morphokinetic evaluation aids fertility treatments.
Area of Science:
- Reproductive biology
- Embryology
- Infertility research
Background:
- Female fertility declines significantly with age.
- Embryo development is a critical factor in successful conception.
Purpose of the Study:
- To investigate the relationship between maternal age and embryo morphokinetic parameters.
- To analyze how maternal age affects embryo cleavage patterns.
Main Methods:
- Retrospective analysis of embryo morphokinetics in women across different age groups (<30, 30-35, 36-40, >40).
- Assessment of key morphokinetic timings (t2-t8) and abnormal cleavage patterns like cell fusion (Fu) and trichotomous mitoses (TM).
Main Results:
- Later occurrence of t5 in women aged 36-40 and >40 years compared to younger groups.
- Increased incidence of cell fusion (Fu) and trichotomous mitoses (TM) in women over 40.
- No significant difference in other morphokinetic timings or uneven blastomeres between age groups.
Conclusions:
- Maternal age is associated with specific embryo cleavage patterns.
- Embryo morphokinetics evaluation can potentially improve embryo selection for patients with advanced maternal age.
- Optimizing embryo selection may enhance fertility outcomes in older women.
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