Related Experiment Video

Updated: Jan 23, 2026

Localization of the Locus Coeruleus in the Mouse Brain
07:44

Localization of the Locus Coeruleus in the Mouse Brain

Published on: March 7, 2019

19.0K

Locus Minoris Resistentiae in Coccidioidomycosis: A Case Series

Namgyal Sherpa1, Rushabh Shah1, Brian Nordstrom1

  • 11 Kern Medical Center, Bakersfield, CA, USA.

Journal of Investigative Medicine High Impact Case Reports
|June 22, 2019
PubMed

Insights

Locus minoris resistentiae, or a weakened body area, can lead to infections spreading to injured sites. Trauma following pulmonary coccidioidomycosis can cause bone dissemination to the injury location.

Area of Science:

  • Infectious Diseases
  • Immunology
  • Orthopedics

Background:

  • Locus minoris resistentiae describes areas of decreased bodily resistance, increasing vulnerability to disease.
  • This concept applies across medical specialties, encompassing both congenital and acquired conditions.
  • Antecedent trauma is a recognized risk factor for hematogenous spread of infections.

Observation:

  • This study examines two patients with pulmonary coccidioidomycosis.
  • Both patients experienced subsequent trauma to specific body regions.
  • The trauma led to osseous dissemination of coccidioidal infection.

Findings:

  • Pulmonary coccidioidomycosis can disseminate to sites of antecedent trauma.
  • Osseous dissemination occurred at the site of injury in both described cases.
  • This highlights the role of locus minoris resistentiae in infectious disease spread.

Implications:

  • Understanding locus minoris resistentiae is crucial for managing disseminated infections.
  • Trauma can create a locus minoris resistentiae, predisposing to localized infection.
  • This has implications for patient care, particularly in endemic areas of coccidioidomycosis.
Keywords:
San Joaquin fevercoccidioidomycosislocus minoris resistentiaevalley fever

More Related Videos

Author Spotlight: Advancing Chromatin Research and Overcoming Limitations with a High-Enrichment Locus-Specific Chromatin Isolation Protocol10:33

Author Spotlight: Advancing Chromatin Research and Overcoming Limitations with a High-Enrichment Locus-Specific Chromatin Isolation Protocol

Published on: November 17, 2023

1.7K
Application of DNA Fingerprinting using the D1S80 Locus in Lab Classes08:35

Application of DNA Fingerprinting using the D1S80 Locus in Lab Classes

Published on: July 17, 2021

23.0K

Related Concept Videos

Locus of Control01:26

Locus of Control

Locus of control describes how individuals perceive the causes of events in their lives, influencing motivation and well-being. Introduced by Julian Rotter in 1954, it is categorized into internal and external locus of control.Internal Locus of ControlIndividuals with an internal locus of control believe their actions determine outcomes, fostering responsibility, self-efficacy, and motivation. For example, an employee may attribute career success to hard work. Research links this mindset to...
211
Root-Locus Method01:19

Root-Locus Method

A cruise control system in a car is designed to maintain a specified speed automatically by adjusting the gas pedal. The system continuously measures the vehicle's speed and makes fine adjustments to the pedal to achieve this goal. The root locus method is particularly useful for understanding how the cruise control system's behavior changes under varying conditions, such as when the car goes uphill, downhill, or faces strong wind resistance.
This system can be represented by a block...
489
Construction of Root Locus01:15

Construction of Root Locus

The construction of a root locus involves several key steps to analyze and visualize the behavior of a system's poles with varying gain. The number of branches in the root locus equals the number of closed-loop poles and is symmetrical about the real axis.
For positive gain values, the root locus exists on the real axis to the left of an odd number of finite open-loop poles or zeros. The root locus starts at the open-loop poles and traces the paths of the closed-loop poles as the gain...
406
Properties of the Root Locus01:05

Properties of the Root Locus

The root locus method is an invaluable tool for analyzing higher-order systems without needing to factor the denominator of the transfer function. A pole of the system is identified when the characteristic polynomial in the transfer function's denominator equals zero.
To determine if a point lies on the root locus, the criterion involves the sum of angles contributed by all poles and zeros to that point. Specifically, this sum must be an odd multiple of 180 degrees. The gain at any point on...
294
Rotter's Locus of Control01:14

Rotter's Locus of Control

Julian Rotter introduced the concept of locus of control, a cognitive factor that significantly influences personality development and learning. Locus of control refers to an individual's beliefs about the extent of control they have over events in their lives. According to Rotter, this belief system can be categorized into two types: internal and external locus of control.
Individuals with an internal locus of control believe that their personal efforts and decisions directly affect their...
916
Resistors In Series01:10

Resistors In Series

A resistor is an ohmic device that limits the flow of charge in a circuit. Most circuits have more than one resistor. If several resistors are connected together and connected to a battery, the current supplied by the battery depends on the equivalent resistance of the circuit. The equivalent resistance of a combination of resistors depends on both their individual values and how they are connected. The simplest combination of resistors is the series combination. 
In a series circuit, the...
6.1K