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Locus Minoris Resistentiae in Coccidioidomycosis: A Case Series
Namgyal Sherpa1, Rushabh Shah1, Brian Nordstrom1
11 Kern Medical Center, Bakersfield, CA, USA.
Summary
Locus minoris resistentiae, or a weakened body area, can lead to infections spreading to injured sites. Trauma following pulmonary coccidioidomycosis can cause bone dissemination to the injury location.
Area of Science:
- Infectious Diseases
- Immunology
- Orthopedics
Background:
- Locus minoris resistentiae describes areas of decreased bodily resistance, increasing vulnerability to disease.
- This concept applies across medical specialties, encompassing both congenital and acquired conditions.
- Antecedent trauma is a recognized risk factor for hematogenous spread of infections.
Observation:
- This study examines two patients with pulmonary coccidioidomycosis.
- Both patients experienced subsequent trauma to specific body regions.
- The trauma led to osseous dissemination of coccidioidal infection.
Findings:
- Pulmonary coccidioidomycosis can disseminate to sites of antecedent trauma.
- Osseous dissemination occurred at the site of injury in both described cases.
- This highlights the role of locus minoris resistentiae in infectious disease spread.
Implications:
- Understanding locus minoris resistentiae is crucial for managing disseminated infections.
- Trauma can create a locus minoris resistentiae, predisposing to localized infection.
- This has implications for patient care, particularly in endemic areas of coccidioidomycosis.
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