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Updated: Jan 23, 2026

Genome-wide Surveillance of Transcription Errors in Eukaryotic Organisms
Published on: September 13, 2018
The Organizing Principles of Eukaryotic Ribosome Recruitment
Jerry Pelletier1,2,3, Nahum Sonenberg1,2
1Department of Biochemistry, McGill University, Montreal, Quebec H3G 1Y6, Canada; email: jerry.pelletier@mcgill.ca , nahum.sonenberg@mcgill.ca.
Abstract:
The stage at which ribosomes are recruited to messenger RNAs (mRNAs) is an elaborate and highly regulated phase of protein synthesis. Upon completion of this step, a ribosome is positioned at an appropriate initiation codon and primed to synthesize the encoded polypeptide product. In most circumstances, this step commits the ribosome to translate the mRNA. We summarize the knowledge regarding the initiation factors implicated in this activity as well as review different mechanisms by which this process is conducted.
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