Related Experiment Video
Updated: Jan 23, 2026
10:43
siRNA Screening to Identify Ubiquitin and Ubiquitin-like System Regulators of Biological Pathways in Cultured Mammalian Cells
Published on: May 24, 2014
11.8K
TRPC1 as a negative regulator for TRPC4 and TRPC5 channels
Jinsung Kim1, Juyeon Ko1, Jongyun Myeong2
1Department of Physiology, College of Medicine, Seoul National University, Seoul, South Korea.
Pflugers Archiv : European Journal of Physiology
|June 22, 2019
Summary
Transient receptor potential canonical (TRPC) 1, 4, and 5 channels are crucial for nervous system functions. This review explores their roles in various diseases and their interactions with calcium influx and voltage-gated calcium channels.
Area of Science:
- Neuroscience
- Molecular Biology
- Ion Channel Physiology
Background:
- Transient receptor potential canonical (TRPC) channels are calcium-permeable cation channels with diverse tissue distribution.
- TRPC channels are classified into TRPC1/4/5 and TRPC3/6/7 subgroups based on sequence homology.
- TRPC4 and TRPC5 form homotetramers and heterotetramers with TRPC1, with TRPC1 being ubiquitously expressed and TRPC4/5 predominantly in the nervous system.
Purpose of the Study:
- To review the function of TRPC1 channels, both individually and in heterotetrameric complexes with TRPC4 and TRPC5.
- To elucidate the involvement of TRPC1/4/5 channels in various neurological and psychiatric disorders.
- To examine the relationship between TRPC1/4/5 channels, calcium influx, and voltage-gated calcium channels.
Main Methods:
- Literature review of studies investigating TRPC1, TRPC4, and TRPC5 channels.
- Analysis of data from heterologous expression systems.
- Examination of findings from conditional knockout studies of TRPC1, TRPC4, and TRPC5 genes.
Main Results:
- TRPC1/4/5 channels are implicated in pathophysiological conditions including seizures, anxiety, fear, Huntington's disease, and Parkinson's disease.
- Studies in heterologous systems have addressed activation mechanisms, stoichiometry, and cation permeabilities of homomeric and heteromeric TRPC channels.
- The role of TRPC1 in the plasma membrane and its contribution to heterotetrameric channels (TRPC1/4, TRPC1/5) are highlighted.
Conclusions:
- TRPC1, TRPC4, and TRPC5 channels play significant roles in the nervous system and are implicated in numerous diseases.
- Understanding the function and regulation of these TRPC channels is crucial for developing therapeutic strategies for neurological disorders.
- Further research is needed to fully elucidate the complex interplay between TRPC channels, calcium signaling, and neuronal function.
Related Concept Videos
01:23Negative Regulator Molecules
38.3K
Positive regulators allow a cell to advance through cell cycle checkpoints. Negative regulators have an equally important role as they terminate a cell’s progression through the cell cycle—or pause it—until the cell meets specific criteria.
38.3K
01:19Ion Channels
91.2K
The movement of ions like sodium, potassium, and calcium into and out of the cell is essential to maintain the electrochemical gradient in living cells. The ion channels—a class of membrane transport proteins—help maintain this ionic gradient for the smooth functioning of physiological activities such as maintaining cell size and volume, conducting nerve impulses, and gas and nutrient exchange.
Ion channels are specialized integral membrane proteins on the plasma membrane that allow...
Ion channels are specialized integral membrane proteins on the plasma membrane that allow...
91.2K
01:46Epigenetic Regulation
33.5K
Epigenetic mechanisms play an essential role in healthy development. Conversely, precisely regulated epigenetic mechanisms are disrupted in diseases like cancer.
33.5K
02:14GTPases and their Regulation
9.8K
Guanine nucleotide-binding proteins (G-proteins), also known as GTPases, are a superfamily of proteins that regulate many cellular processes, such as cell signaling, vesicular transport, and the regulation of cell shape and motility. Mutation or dysfunction of these proteins can lead to disease. There are around 40,000 known G-proteins that can broadly be classified into two groups ‒ small G-proteins consisting of a single domain and large multi-domain G-proteins.
Large G-proteins,...
Large G-proteins,...
9.8K
00:58Positive, Negative, and Zero Work
22.1K
Work is done on an object when energy is transferred to the object. In other words, work is done when a force acts on a body that undergoes a displacement from one position to another. By definition, the work done by a force is the integral of the force with respect to the displacement along its path. Forces can vary as a function of position, and displacements can occur along various paths between two points. The magnitude of a force multiplied by the cosine of the angle that the force makes...
22.1K
02:58Regulated Protein Degradation
8.8K
It is vital to regulate the activity of enzymatic as well as non-enzymatic proteins inside the cell. This can be achieved either through creating a balance between their rate of synthesis and degradation or regulating the intrinsic activity of the protein. Both these regulation mechanisms play an essential role in the normal functioning of cells.
Protein degradation plays two important roles in the cells. It helps to protect cells from misfolded or damaged proteins before they lead to a...
Protein degradation plays two important roles in the cells. It helps to protect cells from misfolded or damaged proteins before they lead to a...
8.8K