Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Inheritance of Chromatin Structures03:17

Inheritance of Chromatin Structures

7.3K
Epigenetics is the study of inherited changes in a cell's phenotype without changing the DNA sequences. It provides a form of memory for the differential gene expression pattern to maintain cell lineage, position-effect variegation, dosage compensation, and maintenance of chromatin structures such as telomeres and centromeres. For example, the structure and location of the centromere on chromosomes are epigenetically inherited. Its functionality is not dictated or ensured by the underlying...
7.3K
Genomic Imprinting and Inheritance02:30

Genomic Imprinting and Inheritance

36.9K
Diploid organisms inherit genetic material through chromosomes from both parents. Copies of the same gene are known as alleles. In most cases, both alleles are simultaneously expressed and allow various cellular processes to function optimally. If one of the alleles is missing or mutated, the expression of the other allele can compensate; however, this is not true for all genes.
The expression of some genes depends on which parent passed the gene to the offspring, through a phenomenon known as...
36.9K
Chromosomal Theory of Inheritance01:39

Chromosomal Theory of Inheritance

59.8K
In 1866, Gregor Mendel published the results of his pea plant breeding experiments, providing evidence for predictable patterns in the inheritance of physical characteristics. The significance of his findings was not immediately recognized. In fact, the existence of genes was unknown at the time. Mendel referred to hereditary units as “factors.”
59.8K
Induced Pluripotent Stem Cells01:13

Induced Pluripotent Stem Cells

27.3K
Stem cells are undifferentiated cells that divide and produce different types of cells. Ordinarily, cells that have differentiated into a specific cell type are post-mitotic—that is, they no longer divide. However, scientists have found a way to reprogram these mature cells so that they “de-differentiate” and return to an unspecialized, proliferative state. These cells are also pluripotent like embryonic stem cells—able to produce all cell types—and are therefore...
27.3K
Ecological Succession02:17

Ecological Succession

21.4K
Ecological succession is influenced by the processes of facilitation, inhibition, and toleration. Facilitation occurs when early successional species create more favorable ecological conditions for subsequent species, such as enhanced nutrient, water, or light availability. In contrast, inhibition happens when early successional species create unfavorable ecological conditions for potential successive species, such as limiting resource availability. In some cases, later successional species...
21.4K
Non-nuclear Inheritance01:29

Non-nuclear Inheritance

23.1K
Most DNA resides in the nucleus of a cell. However, some organelles in the cell cytoplasm⁠—such as chloroplasts and mitochondria⁠—also have their own DNA. These organelles replicate their DNA independently of the nuclear DNA of the cell in which they reside. Non-nuclear inheritance describes the inheritance of genes from structures other than the nucleus.
23.1K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Tuberculosis after allogeneic hematopoietic stem cell transplantation: a decade nationwide case-control retrospective study in low-incidence country.

Bone marrow transplantation·2026
Same author

Completion of the Icatibant Outcome Survey and What We Learned.

Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology·2026
Same author

The International/Canadian hereditary angioedema guideline.

Allergy, asthma, and clinical immunology : official journal of the Canadian Society of Allergy and Clinical Immunology·2026
Same author

Compassionate Use of Olorofim for Invasive Mold Infections: A Nationwide Observational Study in France.

Open forum infectious diseases·2026
Same author

Differential susceptibility of Candida (Candidozyma) auris clades to surface disinfectants.

The Journal of hospital infection·2025
Same author

Targeting Complex Cutaneous Viral Infections in Search of Inborn Errors of Immunity.

Acta dermato-venereologica·2025

Related Experiment Video

Updated: Jan 23, 2026

Transplantation of Tail Skin to Study Allogeneic CD4 T Cell Responses in Mice
06:48

Transplantation of Tail Skin to Study Allogeneic CD4 T Cell Responses in Mice

Published on: July 25, 2014

13.7K

Successful Allogenic Stem Cell Transplantation in Patients with Inherited CARD9 Deficiency.

F Queiroz-Telles1,2, T Mercier3, J Maertens3

  • 1Department of Public Health, Federal University of Parana, Curitiba, Brazil.

Journal of Clinical Immunology
|June 22, 2019
PubMed
Summary

Hematopoietic stem cell transplantation (HSCT) offers a life-saving treatment for individuals with autosomal recessive (AR) CARD9 deficiency, a condition causing severe invasive fungal infections. Successful HSCT led to complete remission in two patients, highlighting its therapeutic potential.

Keywords:
CARD9deep dermatophytosishematopoietic stem cell transplantationinvasive dermatophytic diseaseprimary immunodeficiency

More Related Videos

Generation of Multivirus-specific T Cells to Prevent/treat Viral Infections after Allogeneic Hematopoietic Stem Cell Transplant
08:52

Generation of Multivirus-specific T Cells to Prevent/treat Viral Infections after Allogeneic Hematopoietic Stem Cell Transplant

Published on: May 27, 2011

17.7K
Detection of Residual Donor Erythroid Progenitor Cells after Hematopoietic Stem Cell Transplantation for Patients with Hemoglobinopathies
11:59

Detection of Residual Donor Erythroid Progenitor Cells after Hematopoietic Stem Cell Transplantation for Patients with Hemoglobinopathies

Published on: September 6, 2017

7.8K

Related Experiment Videos

Last Updated: Jan 23, 2026

Transplantation of Tail Skin to Study Allogeneic CD4 T Cell Responses in Mice
06:48

Transplantation of Tail Skin to Study Allogeneic CD4 T Cell Responses in Mice

Published on: July 25, 2014

13.7K
Generation of Multivirus-specific T Cells to Prevent/treat Viral Infections after Allogeneic Hematopoietic Stem Cell Transplant
08:52

Generation of Multivirus-specific T Cells to Prevent/treat Viral Infections after Allogeneic Hematopoietic Stem Cell Transplant

Published on: May 27, 2011

17.7K
Detection of Residual Donor Erythroid Progenitor Cells after Hematopoietic Stem Cell Transplantation for Patients with Hemoglobinopathies
11:59

Detection of Residual Donor Erythroid Progenitor Cells after Hematopoietic Stem Cell Transplantation for Patients with Hemoglobinopathies

Published on: September 6, 2017

7.8K

Area of Science:

  • Immunology
  • Genetics
  • Infectious Diseases

Background:

  • Autosomal recessive (AR) CARD9 deficiency causes severe invasive fungal infections, particularly by ascomycete fungi, in otherwise healthy individuals.
  • The cellular mechanisms underlying these infections in CARD9-deficient patients remain poorly understood.
  • Fungal infections present a significant therapeutic challenge with high mortality rates.

Observation:

  • Two unrelated patients with AR CARD9 deficiency, presenting with invasive dermatophytic disease since childhood, were successfully treated with hematopoietic stem cell transplantation (HSCT).
  • Genetic analysis revealed homozygous missense CARD9 variants (p.R101L and p.R101C) in both patients.
  • Both patients achieved complete clinical remission and discontinued antifungal therapy over three years post-HSCT.

Findings:

  • HSCT, including HLA-matched and T cell-depleted haploidentical approaches, resulted in sustained engraftment and complete remission of invasive fungal infections.
  • The successful treatment suggests that leukocyte-mediated immunity, dependent on CARD9 function, is crucial for controlling fungal infections in these patients.
  • HSCT appears to be a viable and potentially curative option for AR CARD9 deficiency.

Implications:

  • Hematopoietic stem cell transplantation (HSCT) represents a promising therapeutic strategy for patients suffering from autosomal recessive CARD9 deficiency.
  • These findings underscore the critical role of CARD9 in host defense against fungal pathogens, particularly within the myeloid cell compartment.
  • Further research into CARD9-mediated immunity could pave the way for novel therapeutic targets for invasive fungal infections.