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CD73: an emerging checkpoint for cancer immunotherapy

Siqi Chen1, Derek A Wainwright2, Jennifer D Wu3

  • 1Robert H Lurie Comprehensive Cancer Center, Department of Medicine-Division of Hematology/Oncology, Northwestern University Feinberg School of Medicine, Chicago, IL 60611, USA.

Immunotherapy
|June 22, 2019
PubMed

Insights

CD73 blockade, combined with other therapies, shows promise in fighting cancer by boosting immune response. This strategy is effective in preclinical models and early clinical trials for advanced solid tumors.

Area of Science:

  • Oncology
  • Immunology
  • Biochemistry

Background:

  • CD73 is an immune checkpoint enzyme linked to adenosine metabolism.
  • It promotes tumor growth by hindering anti-tumor immunity and encouraging angiogenesis.
  • CD73 plays a role in tumor progression and immune evasion.

Purpose of the Study:

  • To review the role of CD73 in tumor immunity and tumorigenesis.
  • To summarize the antitumor effects of CD73 inhibition in preclinical and clinical settings.
  • To discuss the combination of anti-CD73 therapies with other cancer treatments.

Main Methods:

  • Review of preclinical mouse models of cancer.
  • Analysis of emerging clinical data for advanced solid tumors.
  • Discussion of monoclonal antibodies (mAbs) and small molecule inhibitors targeting CD73.

Main Results:

  • CD73 inhibition, especially combined with immune checkpoint blockade, enhances anti-tumor effects.
  • Preclinical studies demonstrate improved outcomes with CD73 targeting.
  • Early clinical trials show promising activity in patients with advanced solid tumors.

Conclusions:

  • Targeting CD73 is a promising strategy for cancer therapy.
  • Combination therapies involving CD73 inhibition warrant further investigation.
  • CD73 blockade offers a potential approach to overcome tumor-induced immunosuppression.
Keywords:
CD73adenosine receptorimmune checkpoint blockadeimmunotherapytumor evasion

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