Related Experiment Video
Updated: Jan 23, 2026
06:51
Manufacturing Chimeric Antigen Receptor CAR T Cells for Adoptive Immunotherapy
Published on: December 17, 2019
15.9K
CD73: an emerging checkpoint for cancer immunotherapy.
Siqi Chen1, Derek A Wainwright2, Jennifer D Wu3
1Robert H Lurie Comprehensive Cancer Center, Department of Medicine-Division of Hematology/Oncology, Northwestern University Feinberg School of Medicine, Chicago, IL 60611, USA.
Immunotherapy
|June 22, 2019
Summary
CD73 blockade, combined with other therapies, shows promise in fighting cancer by boosting immune response. This strategy is effective in preclinical models and early clinical trials for advanced solid tumors.
Area of Science:
- Oncology
- Immunology
- Biochemistry
Background:
- CD73 is an immune checkpoint enzyme linked to adenosine metabolism.
- It promotes tumor growth by hindering anti-tumor immunity and encouraging angiogenesis.
- CD73 plays a role in tumor progression and immune evasion.
Purpose of the Study:
- To review the role of CD73 in tumor immunity and tumorigenesis.
- To summarize the antitumor effects of CD73 inhibition in preclinical and clinical settings.
- To discuss the combination of anti-CD73 therapies with other cancer treatments.
Main Methods:
- Review of preclinical mouse models of cancer.
- Analysis of emerging clinical data for advanced solid tumors.
- Discussion of monoclonal antibodies (mAbs) and small molecule inhibitors targeting CD73.
Main Results:
- CD73 inhibition, especially combined with immune checkpoint blockade, enhances anti-tumor effects.
- Preclinical studies demonstrate improved outcomes with CD73 targeting.
- Early clinical trials show promising activity in patients with advanced solid tumors.
Conclusions:
- Targeting CD73 is a promising strategy for cancer therapy.
- Combination therapies involving CD73 inhibition warrant further investigation.
- CD73 blockade offers a potential approach to overcome tumor-induced immunosuppression.
Related Concept Videos
02:19The Spindle Assembly Checkpoint
3.7K
The spindle assembly checkpoint is a molecular surveillance mechanism ensuring the fidelity of chromosome segregation during anaphase. The checkpoint monitors the completion of all the prerequisite steps before chromosome segregation to determine whether the segregation process should proceed or be delayed.
Many proteins function together to control the spindle assembly checkpoint. Mutations affecting these proteins may allow cells to proceed into anaphase prematurely, resulting in the...
Many proteins function together to control the spindle assembly checkpoint. Mutations affecting these proteins may allow cells to proceed into anaphase prematurely, resulting in the...
3.7K
01:27Tumor Immunotherapy
1.8K
Immunotherapy is a treatment that boosts or manipulates the immune system to fight diseases, including cancer. For instance, by stimulating an immune response through vaccinations against viruses that cause cancers, like hepatitis B virus and human papillomavirus, these diseases can be prevented. Nonetheless, some cancer cells can avoid the immune system due to their rapid mutation and division. The immune response to many cancers involves three phases: elimination, equilibrium, and escape.
1.8K
01:27Emerging Adulthood
648
Jeffrey Arnett's concept of emerging adulthood offers a framework to understand the unique developmental stage between adolescence and full-fledged adulthood, generally from ages 18 to 25. This period is marked by extensive exploration and shifts in identity, relationships, and career choices, a process known in psychology as role experimentation. Emerging adulthood reflects the evolving cultural expectations surrounding adulthood and the dynamic process of personal transformation during...
648
01:30Introduction Cardiac Emergencies
306
Cardiac emergencies are critical situations involving the heart that require immediate medical intervention to prevent severe complications or death. These emergencies often arise from underlying heart conditions that impair the heart's ability to function correctly.Types of Cardiac EmergenciesThe most common types of cardiac emergencies include Acute Coronary Syndrome (ACS), myocardial infarction (MI), cardiac arrest, and heart failure.Acute Coronary Syndrome (ACS)Acute Coronary Syndrome (ACS)...
306
01:29Applications of GIS: Disaster Management and Emergency Response
488
Geographic Information System (GIS) technology is essential for risk identification, action prioritization, and resource optimization in critical situations like flooding and earthquakes. By integrating spatial and demographic data, GIS provides a comprehensive framework for emergency response.GIS integrates data layers, like rainfall intensity, topography, elevation profiles, and river levels, to model high-risk flood zones. These layers assess areas susceptible to flooding based on their...
488
02:18Cancer
53.8K
Cancers arise due to mutations in genes involved in the regulation of cell division, which leads to unrestricted cell proliferation. Modern science and medicine have made great strides in the understanding and treatment of cancer, including eradicating cancer in some patients. However, there is still no cure for cancer. This is largely due to the fact that cancer is a large group of many diseases.
53.8K