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A Fast and Quantitative Method for Post-translational Modification and Variant Enabled Mapping of Peptides to Genomes
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Native peptide mapping - A simple method to routinely monitor higher order structure changes and relation to

Michel Degueldre1, Annemie Wielant1, Eglantine Girot1

  • 1Department of Analytical Science Biologicals, UCB , Braine L'Alleud , Belgium.

Mabs
|June 22, 2019
PubMed
Summary

Native peptide mapping offers a straightforward method for analyzing higher order structure (HOS) in biopharmaceuticals. This technique proves effective for assessing the stability and structure-activity relationship of IgG antibodies, crucial for drug safety and efficacy.

Keywords:
BioassayBiopharmaceuticalHigher Order StructureMethod Developmentmass spectrometrymonoclonal antibodypeptide mappingquality controlstabilitystructure activity relationship

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