Related Experiment Video

Updated: Jan 23, 2026

Measuring Progressive Neurological Disability in a Mouse Model of Multiple Sclerosis
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Monthly Pulse Methylprednisolone Therapy is Effective in Preventing Permanent Disease Progression in Secondary

Serkan Özakbaş1, Bilge Piri Çinar2, Didem Öz1

  • 1Department of Neurology, Dokuz Eylül University School of Medicine, İzmir, Turkey.

Noro Psikiyatri Arsivi
|June 22, 2019
PubMed
Abstract

Insights

Monthly high-dose intravenous methylprednisolone pulse therapy (IVMP) can stabilize disability and reduce new lesions in secondary progressive multiple sclerosis (SPMS). This treatment may halt or slightly reverse disease progression in SPMS patients.

Area of Science:

  • Neurology
  • Immunology

Background:

  • Secondary progressive multiple sclerosis (SPMS) is characterized by continuous disability worsening.
  • Monthly methylprednisolone pulse therapy is a potential treatment option for SPMS.

Purpose of the Study:

  • To evaluate the efficacy of monthly methylprednisolone pulse therapy in SPMS patients.
  • To assess the impact of IVMP on clinical and MRI parameters.

Main Methods:

  • A multi-center, prospective, examiner-blinded study.
  • 97 SPMS patients with EDSS scores ≥3 received 1g IVMP monthly for 24 months.
  • Evaluated EDSS scores, MRI lesions, quality of life, and adverse events.

Main Results:

  • Significant reduction in new/enlarging and Gd-enhanced lesions observed.
  • EDSS scores remained stable over 24 months.
  • Monthly IVMP significantly decreased the frequency of attacks.

Conclusions:

  • Monthly pulse therapy with methylprednisolone can halt or partially reverse SPMS progression.
  • This therapeutic option warrants consideration for managing SPMS.
  • IVMP demonstrates a positive effect on key disease markers in SPMS.
Keywords:
Secondary progressive multiple sclerosisdisease progressionmonthly methylprednisolone treatment

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