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Long-term depression, or LTD, is one of the ways by which synaptic plasticity—changes in the strength of chemical synapses—can occur in the brain. LTD is the process of synaptic weakening that occurs over time between pre and postsynaptic neuronal connections. The synaptic weakening of LTD works in opposition to synaptic strengthening by long-term potentiation (LTP) and together are the main mechanisms that underlie learning and memory.
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Related Experiment Video

Updated: Jan 23, 2026

Author Spotlight: Unveiling the Connection Between Sleep Disorders and Cognitive Symptoms in Depression
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Author Spotlight: Unveiling the Connection Between Sleep Disorders and Cognitive Symptoms in Depression

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Optimal Well-Being after Major Depression.

Jonathan Rottenberg1, Andrew R Devendorf1, Vanessa Panaite1

  • 1University of South Florida.

Clinical Psychological Science : a Journal of the Association for Psychological Science
|June 22, 2019
PubMed
Summary

Many adults can achieve optimal well-being and thrive after major depression. Nearly 10% of adults with depression showed thriving outcomes 10 years later, challenging previous epidemiological views.

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Area of Science:

  • Psychiatry
  • Epidemiology
  • Psychology

Background:

  • Contemporary epidemiology often views major depression as a chronic, recurrent condition with a poor prognosis.
  • This perspective overlooks the potential for individuals to achieve optimal well-being and thrive post-depression.

Purpose of the Study:

  • To estimate the prevalence of thriving after major depression in United States adults.
  • To challenge the prevailing epidemiological view of depression's prognosis.

Main Methods:

  • Utilized data from the Midlife Development in the United States (MIDUS) study.
  • Defined thriving as no evidence of major depression plus exceeding established cutoffs in nine psychological well-being facets (top 25% of non-depressed adults).
  • Assessed outcomes ten years after initial depression diagnosis.

Main Results:

  • Nearly 10% of adults with documented depression were thriving ten years later.
  • This finding indicates that thriving post-depression is a tangible phenomenon.

Conclusions:

  • The possibility of thriving after depression has significant implications for conceptualizing depression's prognosis.
  • Mental health professionals can leverage this understanding to improve patient communication and treatment strategies.
  • Identifying factors contributing to thriving can offer new avenues to reduce the global burden of depression.