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Updated: Jan 23, 2026
07:45
Retroductal Nanoparticle Injection to the Murine Submandibular Gland
Published on: May 3, 2018
10.7K
Seek the Spindle Tumor in Submandibular Space.
Deviprasad Dosemane1, Urmila Khadilkar2, Meera Khadilkar1
1Department of Otorhinolaryngology, Kasturba Medical College, Mangalore, Manipal Academy of Higher Education. India.
Iranian Journal of Otorhinolaryngology
|June 22, 2019
Summary
An inflammatory myofibroblastic tumor (IMT) was diagnosed in an elderly man with a submandibular swelling. Surgical excision and radiotherapy led to no recurrence six months post-treatment.
Area of Science:
- Head and Neck Surgery
- Oncology
- Pathology
Background:
- The submandibular region is surgically critical, with masses presenting diverse diagnostic challenges.
- Spindle cell lesions in the head and neck require careful differential diagnosis.
Observation:
- An elderly male presented with a month-long right-sided neck swelling below the jaw.
- Ultrasound revealed a heterogeneous, hypoechoic lesion in the right submandibular space.
- Fine needle aspiration suggested a spindle cell neoplasm.
Findings:
- Histopathology confirmed an anaplastic lymphoma kinase-negative inflammatory myofibroblastic tumor (IMT).
- Diagnosis was supported by focal cyclin D1 immunoreactivity.
- The patient underwent surgical excision followed by radiotherapy (60 Gy/30 fractions).
Implications:
- Definitive diagnosis of IMT is crucial for appropriate treatment planning due to its locally aggressive potential.
- This case highlights the importance of considering IMT in tumefactive spindle-cell lesions of the head and neck.
- Successful management with surgery and radiotherapy resulted in no evidence of disease at six months.
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