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Immunohistochemical detection of cathepsin D in human neuroontogenesis
A Müller1, H G Bernstein, B Wiederanders
1Institute of Anatomy, Medical Academy Magdeburg, GDR.
Acta Histochemica
|January 1, 1987
Abstract:
An antiserum against rat liver cathepsin D, which was previously found to cross-react with human brain cathepsin(s) D, was used to immunolocalize the enzyme in developing CNS man. Cathepsin D protein was found in neurons as well as in glial cells. The aerliest occurrence of cathepsin D was observed in neuroblasts at the 12th gestational week. During pre-, peri-, and postnatal neuroontogenesis, there is a strong increase in the amount of immunoreactive material.