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Updated: Jan 23, 2026
07:09
Isolation of Adipose Tissue Immune Cells
Published on: May 22, 2013
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Tissue-resident memory T cells orchestrate tumour-immune equilibrium
Simone L Park1, Laura K Mackay1, Jason Waithman2
1Department of Microbiology and Immunology, The University of Melbourne at the Peter Doherty Institute for Infection and Immunity, Melbourne, VIC, Australia.
Cell Stress
|June 22, 2019
Summary
Tissue-resident memory T (TRM) cells are crucial for maintaining a balance between cancer cells and the immune system in the skin. Targeting these TRM cells may offer a new strategy for cancer treatment.
Area of Science:
- Immunology
- Oncology
- Cell Biology
Background:
- The immune system, through cancer immunosurveillance, eliminates or controls tumour growth.
- Circulating T cells are typically excluded from epithelial tissues, hindering immunosurveillance.
- CD8+ tissue-resident memory T (TRM) cells reside in epithelial tissues and are linked to better cancer prognosis.
Purpose of the Study:
- To investigate the mechanisms by which TRM cells mediate cancer protection.
- To understand the role of TRM cells in establishing and maintaining tumour-immune equilibrium in the skin.
Main Methods:
- Development of a melanoma model in mice.
- Analysis of TRM cell function in tumour-immune interactions within the skin.
Main Results:
- TRM cells play a critical role in establishing and maintaining tumour-immune equilibrium in the skin.
- The study identified specific immune cell populations involved in long-term tumour dormancy in peripheral tissues.
Conclusions:
- TRM cells are key players in controlling tumour growth within epithelial tissues.
- Targeting TRM cells represents a potential novel therapeutic strategy for cancer treatment.
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