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Molecular Modulation by Lentivirus-Delivered Specific shRNAs in Endoplasmic Reticulum Stressed Neurons
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Multifaceted role of CNPY2 beyond ER stress: Disease implications and therapeutic potential

Shima Ebadollahibaruq1,2, Lingbin Meng2, Feng Hong1,2

  • 1Pelotonia Institute for Immune-Oncology, The Ohio State University Comprehensive Cancer Center, The Ohio State University Wexner Medical Center, 410 W 12th Ave, Columbus, OH, 43210, USA.

Cell Stress
|April 22, 2026
PubMed

Insights

Canopy homolog protein 2 (CNPY2) is vital for cellular homeostasis and impacts cancer progression. This review explores CNPY2

Area of Science:

  • Molecular Biology
  • Cellular Biology
  • Biochemistry

Background:

  • Canopy homolog protein 2 (CNPY2) is an endoplasmic reticulum (ER) luminal protein involved in cellular homeostasis.
  • CNPY2 regulates critical cellular processes including unfolded protein responses (UPR), mitochondrial dynamics, oxidative stress, and apoptosis.
  • CNPY2 plays roles in both cancer and non-cancer conditions.

Purpose of the Study:

  • To dissect the structural characteristics, expression patterns, and biological functions of CNPY2.
  • To emphasize CNPY2's role in tumor initiation, microenvironmental stress, and chemoresistance.
  • To evaluate CNPY2 as a potential therapeutic target.

Main Methods:

  • Literature review of CNPY2's functions.
  • Analysis of CNPY2's role in cancer pathways (NF-κB, AKT/GSK3β, PI3K/Akt/mTOR, HIF-1α).
  • Examination of CNPY2's involvement in neurodegenerative and cardiovascular diseases.

Main Results:

  • CNPY2 promotes cancer progression via EMT, tumor survival, and metastasis.
  • CNPY2 exerts neuroprotective effects by reducing oxidative stress and mitochondrial dysfunction in neurodegenerative disorders.
  • CNPY2 facilitates hypoxia-driven angiogenesis, tissue repair, and ischemia-reperfusion protection in cardiovascular tissues.

Conclusions:

  • CNPY2 exhibits diverse tissue-specific roles in cancer, cardiovascular disease, inflammation, and neurological disorders.
  • CNPY2's involvement in tumor initiation, microenvironmental stress, and chemoresistance highlights its significance in oncology.
  • CNPY2 represents a promising therapeutic target for various diseases.
Keywords:
Canopy homolog protein 2Endoplasmic reticulum stresscancercardiovascular diseaseneurodegenerative diseasetumor microenvironmentunfolded protein responses

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