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A mild uncompensated alkalosis in anemia
P Pootrakul1, P Yansukon, A Thongmee
1Thalassemia Center, Bangkok, Thailand.
The American Journal of the Medical Sciences
|December 1, 1987
Summary
Anemia, including thalassemia, can cause mild, uncompensated metabolic alkalosis. Blood pH and bicarbonate levels showed consistent changes across different anemia types, unaffected by anemia severity.
Area of Science:
- Hematology
- Clinical Biochemistry
Background:
- Anemia is a common condition with various subtypes.
- Understanding acid-base balance in anemia is crucial for patient management.
Purpose of the Study:
- To investigate blood pH and bicarbonate changes in patients with different types of anemia.
- To determine if anemia severity or erythropoiesis affects acid-base balance.
Main Methods:
- Blood samples were analyzed for pH and bicarbonate levels.
- Subjects included normal individuals and patients with thalassemia, aplastic anemia, and iron deficiency anemia.
Main Results:
- Patients with anemia exhibited mean increases in blood pH (0-0.04) and decreases in bicarbonate (2.3-3.5 mEq/L).
- These changes were consistent across thalassemia, aplastic anemia, and iron deficiency anemia groups.
- Acid-base alterations were not significantly influenced by the degree of erythropoiesis or anemia severity.
Conclusions:
- Anemia is associated with mild, uncompensated metabolic alkalosis.
- The observed acid-base changes are consistent regardless of anemia type or severity.