Potentiometric detection in liquid chromatographic systems: An overview
R L Gil1, C G Amorim1, M C B S M Montenegro1
1LAQV-REQUIMTE/Departamento de Ciências Químicas, Faculdade de Farmácia - Universidade do Porto, R. Jorge, Viterbo Ferreira, 228. 4050-313, Porto, Portugal.
Journal of Chromatography. A
|June 23, 2019
Summary
Potentiometric detection using ion-selective electrodes offers a sensitive and selective alternative for liquid chromatography. This overlooked technique shows great potential for various analytical applications, rivaling established methods.
Area of Science:
- Analytical Chemistry
- Electrochemistry
Background:
- Liquid chromatography (LC) commonly uses optical detectors for quality and safety analysis.
- Electroanalytical techniques offer high selectivity, sensitivity, and cost-effective instrumentation for rapid analysis.
- While amperometric, coulometric, and conductimetric detectors are established in HPLC, potentiometric detectors remain underutilized.
Purpose of the Study:
- To provide an overview of potentiometric detection in liquid chromatography.
- To highlight the potential of potentiometry as a competitive detection technique.
- To emphasize the importance of potentiometric detection for future analytical applications.
Main Methods:
- Review of existing literature on potentiometric detection in hydrodynamic separation systems.
- Discussion of applications in batch and flow analysis.
- Exploration of ion-selective electrode applications in analytical chemistry.
Main Results:
- Potentiometry with ion-selective electrodes has demonstrated significant potential in various analytical fields.
- Numerous applications exist for determining electrolytes, heavy metals, and pharmaceuticals.
- Hydrodynamic separation systems have advanced, proving potentiometry's viability.
Conclusions:
- Potentiometric detection is a valuable, yet overlooked, technique in liquid chromatography.
- Its sensitivity, selectivity, and cost-effectiveness make it a strong contender against other detection methods.
- Further exploration and adoption of potentiometric detection are encouraged for broader analytical applications.
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