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Digital Home-Monitoring of Patients after Kidney Transplantation: The MACCS Platform
Published on: April 12, 2021
"Smartphone Medication Adherence Saves Kidneys" for Kidney Transplantation Recipients: Protocol for a Randomized
John McGillicuddy1, Jessica Chandler2, Luke Sox2
1College of Medicine, Medical University of South Carolina, Charleston, SC, United States.
JMIR Research Protocols
|June 23, 2019
Summary
Smartphone Medication Adherence Saves Kidneys (SMASK) improved medication adherence and blood pressure control in kidney transplant recipients. This mobile health system shows promise for better patient outcomes and graft survival.
Area of Science:
- Nephrology
- Transplantation Medicine
- Digital Health
Background:
- Poor medication adherence and uncontrolled hypertension are significant risks for kidney transplant recipients, leading to graft rejection, loss, and mortality.
- Few randomized controlled trials (RCTs) have successfully improved sustained medication adherence and blood pressure control in this population.
- The Smartphone Medication Adherence Saves Kidneys (SMASK) system is proposed as a mobile health intervention to address these challenges.
Purpose of the Study:
- To evaluate the efficacy of the SMASK mobile health system in improving medication adherence and sustaining blood pressure control among kidney transplant recipients with uncontrolled hypertension.
- To compare the SMASK intervention against enhanced standard care in a randomized controlled trial.
Main Methods:
- A 6-month, phase II, single-site efficacy RCT involving 80 kidney transplant recipients randomly assigned to either the SMASK intervention or enhanced standard care.
- The SMASK intervention includes automated reminders, tailored text messages based on self-determination theory, and provider reports.
- Outcomes assessed at 3, 6, and 12 months include medication adherence, blood pressure control (Kidney Disease Improving Global Outcomes guidelines), provider adherence, and exploratory measures like eGFR and calcineurin inhibitor levels.
Main Results:
- Enrollment of 80 participants was completed by July 2018, with the project receiving funding in June 2016 and IRB approval in April 2016.
- Data collection commenced in July 2016, indicating the study is actively progressing.
Conclusions:
- The study aims to provide efficacy data for SMASK in enhancing medication adherence and blood pressure control in hypertensive kidney transplant recipients.
- A successful SMASK intervention could lead to larger, multicenter trials to assess effectiveness in real-world settings and potentially reduce healthcare costs.
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