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Candida auris and multidrug resistance: Defining the new normal
1Mycotic Diseases Branch, Centers for Disease Control and Prevention, Atlanta, GA, United States.
Fungal Genetics and Biology : FG & B
|June 23, 2019
Summary
Candida auris is a yeast causing difficult-to-treat infections due to widespread antifungal resistance. This review covers resistance mechanisms, testing, and new treatments for this emerging pathogen.
Area of Science:
- Medical Mycology
- Infectious Diseases
- Antimicrobial Resistance
Background:
- Candida auris is an emerging yeast species causing global health concerns.
- It exhibits colonization, environmental persistence, and significant antifungal resistance.
- First described in 2009, it has spread to over 25 countries.
Purpose of the Study:
- To review current knowledge on antifungal resistance in Candida auris.
- To discuss limitations in antifungal susceptibility testing.
- To explore resistance mechanisms and emerging therapeutic agents.
Main Methods:
- Literature review of studies on Candida auris and antifungal resistance.
- Analysis of reported resistance mechanisms and clinical trial data.
- Synthesis of information on new antifungal agents.
Main Results:
- Fluconazole and amphotericin B resistance are common; echinocandin resistance is emerging.
- Antifungal resistance is acquired, with determined mechanisms for azoles and echinocandins.
- New antifungal agents in development show activity against Candida auris.
Conclusions:
- Candida auris poses a significant challenge due to its resistance profile.
- Understanding resistance mechanisms is crucial for effective treatment.
- Emerging antifungal therapies offer hope for managing C. auris infections.
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