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[Absence of paradoxical sleep rebound in hypophysectomized rats pretreated at birth with sodium glutamate]
J X Zhang1, J L Valatx, M Jouvet
1Département de Physiologie, Faculté de Médecine de Anhui, Hoffi, République Populaire de Chine.
Insights
Monosodium glutamate (MSG) pretreatment in newborn rats blocks the normal increase in paradoxical sleep (PS) rebound after deprivation in hypophysectomized adults. This suggests arcuate nucleus or pituitary factors regulate PS rebound mechanisms.
Area of Science:
- Neuroscience
- Endocrinology
- Sleep Research
Abstract:
Control untreated female rats and rats pretreated at birth with ten injections of monosodium glutamate (MSG; 4 mg/g b.w.) were hypophysectomized (Hypox) at 45-60 days of age and their sleep-waking cycle continuously registered. After 24 hrs. of PS deprivation, there was an immediate increase of PS (rebound) in the control Hypox and MSG rats while there was no increase in Hypox-MSG rats. Factors from arcuate nucleus and/or from the hypophysis are probably involved in the mechanisms of PS rebound.