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Aging and Hematopoiesis

Emma M Groarke1, Neal S Young1

  • 1Hematology Branch, National Heart, Lung, and Blood Institute, National Institutes of Health, Mark Hatfield Clinical Research Center, Room 3E-5140, 10 Center Drive, Bethesda, MD 20891-1202, USA.

Clinics in Geriatric Medicine
|June 25, 2019
PubMed

In hematopoiesis, mature blood cells, granulocytes, erythrocytes, and megakaryocytes originate from hematopoietic stem cells. With age, changes in hematopoiesis may have clinical consequences: defective immune responses, cytopenias (most commonly anemia and lymphopenia), hematological malignancy, and effects mediated by hematopoietic cells in other organs. Clonal hematopoiesis is commonly seen with aging and has been associated with both blood concerns and atherosclerosis, but further study is required to determine a causative link.

Keywords:
Anemia in the elderlyClonal cytopenia of undetermined significanceClonal hematopoiesis of indeterminate potentialHematopoiesis

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