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The process of blood cell formation is called hematopoiesis. Hematopoiesis starts early during development, on the seventh day of embryogenesis. This phase of hematopoiesis is called the primitive wave, wherein the extraembryonic yolk sac allows the production of erythroid cells and endothelial cells from a common precursor called hemangioblast. The erythroid cells provide oxygen to support the growth of the rapidly dividing embryo. Hemangioblasts later develop into hematopoietic stem cells or...
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Aging and Hematopoiesis.

Emma M Groarke1, Neal S Young1

  • 1Hematology Branch, National Heart, Lung, and Blood Institute, National Institutes of Health, Mark Hatfield Clinical Research Center, Room 3E-5140, 10 Center Drive, Bethesda, MD 20891-1202, USA.

Clinics in Geriatric Medicine
|June 25, 2019
PubMed
Summary

Aging impacts blood cell production (hematopoiesis), potentially causing immune issues, anemia, and blood cancers. Clonal hematopoiesis, common in older adults, is linked to blood disorders and atherosclerosis, though causality needs more research.

Keywords:
Anemia in the elderlyClonal cytopenia of undetermined significanceClonal hematopoiesis of indeterminate potentialHematopoiesis

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Area of Science:

  • Hematology
  • Immunology
  • Gerontology

Background:

  • Hematopoiesis is the process of blood cell formation from hematopoietic stem cells.
  • Aging alters hematopoiesis, leading to clinical issues like immune dysfunction, cytopenias (anemia, lymphopenia), and hematological malignancies.
  • Clonal hematopoiesis, prevalent in aging, presents associations with hematological and cardiovascular conditions.

Purpose of the Study:

  • To summarize the age-related changes in hematopoiesis.
  • To highlight the clinical consequences of altered hematopoiesis with aging.
  • To discuss the association of clonal hematopoiesis with aging-related diseases.

Main Methods:

  • Literature review of hematopoiesis and aging.
  • Analysis of clinical consequences of age-related hematopoietic changes.
  • Review of studies on clonal hematopoiesis and associated conditions.

Main Results:

  • Aging affects hematopoietic stem cell function and differentiation.
  • Age-related hematopoiesis changes contribute to immune decline, anemia, and increased cancer risk.
  • Clonal hematopoiesis is a common aging finding linked to blood disorders and atherosclerosis.

Conclusions:

  • Age-related hematopoietic alterations have significant clinical implications.
  • Clonal hematopoiesis is a key feature of aging with potential links to atherosclerosis.
  • Further research is needed to establish causative relationships in aging hematopoiesis and disease.