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Updated: Jan 23, 2026

Integrated Photoacoustic Ophthalmoscopy and Spectral-domain Optical Coherence Tomography
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[Optical coherence tomography of bladder resection specimen].

J Anract1, I Duquesne1, P Montagne2

  • 1Service d'urologie, hôpital Cochin, 163, boulevard de Port-Royal, 75014 Paris, France.

Progres En Urologie : Journal De L'Association Francaise D'Urologie Et De La Societe Francaise D'Urologie
|June 25, 2019
PubMed
Summary

Full field optical coherence tomography (FFOCT) shows promise for analyzing bladder tumor resection specimens, accurately detecting muscle and tumor presence. This technique could reduce treatment delays and improve surgical procedures.

Keywords:
Bladder cancerBladder resectionFFOCTRésection de vessieStadificationStagingTumeur de vessieTumeur urothélialeUrothelial tumor

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Area of Science:

  • Urology
  • Medical Imaging
  • Pathology

Background:

  • Bladder urothelial tumor diagnosis relies on histological analysis of resected specimens.
  • Current methods face delays in results, impacting treatment timelines.
  • Inadequate muscle presence in specimens necessitates additional surgical procedures.

Purpose of the Study:

  • To assess the feasibility of Full Field Optical Coherence Tomography (FFOCT) for analyzing bladder resection specimens.
  • To evaluate the diagnostic accuracy of FFOCT in detecting muscle and tumor within these specimens.

Main Methods:

  • FFOCT imaging was applied to bladder resection specimens from 24 consecutive patients.
  • Three blinded readers analyzed FFOCT images for muscle and tumor presence.
  • Results were compared against histological analysis to determine diagnostic accuracy.

Main Results:

  • Mean sensitivity for muscle detection was 75%; for tumor detection, it was 81%.
  • Mean specificity for muscle detection was 78.3%; for tumor detection, it was 55.3%.
  • FFOCT demonstrated feasibility in analyzing bladder resection specimens.

Conclusions:

  • FFOCT is a feasible technique for analyzing bladder resection specimens.
  • The calculated sensitivities and specificities are encouraging for detecting muscle and tumor.
  • Larger studies are needed to validate FFOCT as an accurate early-staging tool.