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Updated: Jan 23, 2026

A Microwave-Assisted Direct Heteroarylation of Ketones Using Transition Metal Catalysis
Published on: February 16, 2020
Transition metal-free assembly of 1,3,5-triazines using ethyl bromodifluoroacetate as C1 source
Xiaoxia Yu1, Yao Zhou, Xingxing Ma
1Institute of Next Generation Matter Transformation, College of Chemical Engineering and College of Materials Science & Engineering at Huaqiao University, Xiamen, Fujian, P. R. China. qsong@hqu.edu.cn.
Abstract:
An efficient transition metal-free annulation of amidine with ethyl bromodifluoroacetate to access 2,4-disubstituted-1,3,5-triazines is firstly presented. The desired symmetric and unsymmetric 2,4-disubstituted-1,3,5-triazines were obtained in decent yields via multiple C-N bond formation, in which ethyl bromodifluoroacetate is harnessed as a unique C1 synthon via quadruple cleavage. This reaction is transition metal-free, oxidant-free and simple in operation, and only lowly toxic inorganic wastes are generated.
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