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Robust pCASL perfusion imaging using a 3D Cartesian acquisition with spiral profile reordering (CASPR)
Joshua S Greer1,2, Xinzeng Wang2, Yiming Wang2
1Department of Bioengineering, University of Texas at Dallas, Richardson, Texas.
Magnetic Resonance in Medicine
|June 25, 2019
Summary
This study introduces a new method, Cartesian acquisition with spiral profile reordering (CASPR) 3D turbo spin echo (TSE), for robust arterial spin-labeled perfusion imaging. The CASPR 3D TSE technique enhances signal-to-noise ratio and provides reliable perfusion measurements in the brain and kidneys.
Area of Science:
- Magnetic Resonance Imaging
- Medical Physics
- Radiology
Background:
- Arterial spin-labeling (ASL) is a non-invasive MRI technique for measuring tissue perfusion.
- Improving the robustness and signal-to-noise ratio (SNR) of ASL is crucial for accurate quantitative perfusion assessment.
- Conventional ASL methods, such as 2D EPI and 3D GRE/TSE, have limitations in coverage and SNR.
Purpose of the Study:
- To evaluate a novel Cartesian acquisition with spiral profile reordering (CASPR) 3D turbo spin echo (TSE) sequence for robust ASL perfusion imaging.
- To compare the performance of CASPR 3D TSE against established ASL techniques in the brain and kidneys.
- To assess the SNR and quantitative perfusion values obtained with the CASPR 3D TSE method.
Main Methods:
- A novel CASPR 3D TSE sequence was developed, featuring pseudo-spiral trajectory and center k-space sampling at the beginning of each echo train.
- Fourteen healthy subjects (9 brain, 5 kidney) underwent ASL perfusion imaging using 3D CASPR TSE.
- Comparisons were made against 3D linear TSE, 2D EPI, 3D GRE/TSE, and 2D single-shot TSE acquisitions.
Main Results:
- 3D CASPR TSE demonstrated robust perfusion across all slices in both brain and kidney imaging compared to 3D linear TSE.
- In brain imaging, 3D CASPR TSE achieved significantly higher SNR than 2D EPI and showed good agreement in quantitative perfusion values.
- For kidney imaging, 3D CASPR TSE provided robust perfusion across the entire organ within a similar scan time and comparable perfusion values to 2D single-shot TSE.
Conclusions:
- The CASPR view ordering combined with 3D TSE provides robust ASL perfusion measurements in the brain and kidneys.
- Sampling the center of k-space early in the echo train is key to the improved performance of the CASPR 3D TSE technique.
- This novel sequence offers a promising alternative for accurate and reliable ASL perfusion imaging.
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