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Noninvasive Sampling of Mucosal Lining Fluid for the Quantification of In Vivo Upper Airway Immune-mediator Levels
Published on: August 7, 2017
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Across-shift changes in upper airways after exposure to bacterial cell wall components.
Marcin Cyprowski1, Agata Stobnicka-Kupiec2, Rafał L Górny3
1Depertment of Chemical, Aerosol and Biological Hazards, Central Institute for Labour Protection - National Research Institute, Warsaw, Poland. macyp@o2.pl.
Annals of Agricultural and Environmental Medicine : AAEM
|June 25, 2019
Summary
Occupational exposure to organic dust, endotoxins, and peptidoglycans significantly increases interleukin-8 (IL-8) levels in nasal lavage. These findings highlight the impact of bioaerosols on inflammatory responses in workers.
Area of Science:
- Occupational Health and Environmental Science
- Immunology
- Toxicology
Background:
- Workers in occupational environments are exposed to bacterial cell wall components in organic dust.
- Assessing across-shift changes in cytokine concentrations in nasal lavage (NAL) is crucial for understanding inflammatory responses.
Purpose of the Study:
- To evaluate the impact of occupational exposure to organic dust on cytokine concentrations in nasal lavage.
- To investigate the relationship between specific bioaerosol components and inflammatory markers in exposed workers.
Main Methods:
- 38 employees from a waste sorting plant (WSP), sewage treatment plant (STP), and an office building (OB) participated.
- Nasal lavage (NAL) samples were analyzed for Interleukin-8 (IL-8) before and after work shifts.
- Personal bioaerosol measurements assessed organic dust, endotoxins (END), and peptidoglycans (PGN).
Main Results:
- IL-8 was the only consistently detectable cytokine.
- WSP workers showed significantly higher IL-8 levels post-shift (p=0.007) and during shifts (p=0.015).
- Organic dust and endotoxins were key factors influencing IL-8 level changes (p<0.001).
Conclusions:
- Occupational exposure to organic dust and its components significantly elevates IL-8 levels.
- Changes in bioaerosol composition can alter inflammatory response mechanisms in exposed workers.
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