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Cytotoxic p-terphenyls from the deep-sea-derived Aspergillus candidus
Yu-Kun Lin1,2, Chun-Lan Xie2, Cui-Ping Xing2
1School of Traditional Chinese Medicine, Shenyang Pharmaceutical University, Shenyang, China.
Abstract:
From the deep-sea-derived fungus Aspergillus candidus, one novel (1) and three known (2-4) p-terphenyl derivates were isolated. The structure of the new compound was established mainly on the basis of extensive analysis of 1D and 2D NMR data. All four isolates were tested for in vitro anti-food allergic and antitumor bioactivities. Compounds 3 and 4 showed potent antiproliferative effect against four cancer cells of Hela, Eca-109, Bel-7402, and PANC-1 with IC50 values ranging from 5.5 μM to 9.4 μM.
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