Related Experiment Video
Updated: Jan 23, 2026
22:10
Multi-target Parallel Processing Approach for Gene-to-structure Determination of the Influenza Polymerase PB2 Subunit
Published on: June 28, 2013
13.7K
Gene-targeting approaches for movement disorders: recent advances
1Department of Neurological Surgery, Weill Cornell Medical College, New York, New York, USA.
Current Opinion in Neurology
|June 25, 2019
Summary
Gene therapy for Parkinson's disease shows promise, with successful clinical trials using gene for glutamic acid decarboxylase (GAD) and viral vectors. Emerging technologies may enable noninvasive gene delivery, advancing treatment options.
Area of Science:
- Neuroscience
- Genetics
- Medical Research
Background:
- Parkinson's disease is a neurodegenerative disorder affecting motor control.
- Current treatments primarily manage symptoms, highlighting the need for disease-modifying therapies.
Purpose of the Study:
- To review the current advancements in gene therapy for Parkinson's disease.
- To highlight recent clinical successes and emerging technologies.
Main Methods:
- Review of clinical trials involving gene therapy for Parkinson's disease.
- Analysis of recent PET imaging data.
- Discussion of novel gene delivery technologies.
Main Results:
- Successful randomized, double-blind trial introducing the glutamic acid decarboxylase (GAD) gene.
- Viral vector strategies showing promising responses in human participants.
- Emerging noninvasive focused ultrasound technology for blood-brain barrier opening.
Conclusions:
- Gene therapy for Parkinson's disease has progressed significantly from animal research to late-stage clinical trials.
- Recent successes and new technologies are poised to accelerate clinical adoption of gene therapy.
Related Concept Videos
01:29Theoretical Approaches to Psychological Disorder
814
The development of psychological disorders, which are characterized by deviant, maladaptive, and personally distressing behaviors, has been explored through several theoretical approaches.
Biological approach
The biological approach posits that internal, organic factors are the primary causes of such disorders. This perspective emphasizes brain structure and function, genetic predispositions, and neurotransmitter imbalances. For example, schizophrenia has been associated with both genetic...
Biological approach
The biological approach posits that internal, organic factors are the primary causes of such disorders. This perspective emphasizes brain structure and function, genetic predispositions, and neurotransmitter imbalances. For example, schizophrenia has been associated with both genetic...
814
02:18Intrinsically Disordered Proteins
19.2K
Intrinsically disordered proteins are a group of proteins that do not fold into specific three-dimensional structures. Their structural flexibility allows them to complement ordered proteins to perform functions that are inaccessible to rigid structures. They are more common in eukaryotes than prokaryotes and may either be exclusively intrinsically disordered or hybrid proteins, consisting of a mix of ordered and disordered regions. The absence of a rigid structure in these proteins can be...
19.2K
00:51Anatomical Movements
15.4K
Anatomical movements refer to the various actions or motions that can be performed by the body's joints and muscles. These movements are described using specific terms to provide a standardized way of discussing and understanding the range of motion at different joints.
Here are some common anatomical movements:
Flexion and extension motions are in the sagittal (anterior–posterior) plane of motion. These movements take place at the shoulder, hip, elbow, knee, wrist,...
Here are some common anatomical movements:
Flexion and extension motions are in the sagittal (anterior–posterior) plane of motion. These movements take place at the shoulder, hip, elbow, knee, wrist,...
15.4K
01:43The Movement of Organelles and Vesicles
6.2K
In eukaryotic cells, cytoskeletal filaments such as actin, microtubules, and intermediate filaments form a mesh-like cytoskeletal network. These filaments serve as tracks for transporting cellular cargo. Specialized motor proteins use the chemical energy stored in adenosine triphosphate (ATP) for this transport. During interphase, microtubules are polarized, with the plus-end towards the cell periphery and the minus-end towards the cell center. Two microtubule-associated motor proteins,...
6.2K
01:27Movement Joints in Buildings
339
Movement joints in buildings are essential design elements that accommodate inevitable motions caused by various factors such as temperature changes, moisture content variations, and structural deflections. These motions, if not considered in design and construction, can lead to unsightly or dangerous damage. Movement joints are incorporated in different forms to manage these stresses and allow materials to move without causing distress.
The simplest type of movement joints, working joints, are...
The simplest type of movement joints, working joints, are...
339
01:18Fluid Movement Between Compartments
3.8K
The force applied by fluids against a surface, known as hydrostatic pressure, initiates the transfer of fluid among different compartments. Within our blood vessels, the blood's hydrostatic pressure is a result of the heart's pumping action. At the arteriolar end of capillaries, hydrostatic pressure (capillary blood pressure) exceeds the opposing colloid osmotic pressure created primarily by plasma proteins like albumin. This discrepancy in pressure propels plasma and nutrients from the...
3.8K