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Published on: August 12, 2011
Lambert-Eaton myasthenic syndrome and merkel cell carcinoma
Nam D Nguyen1, Daniel B Simmons2, Adrian R Bersabe3
1Department of Internal Medicine, San Antonio Military Medical Center, Fort Sam Houston, Texas, USA.
Abstract:
Lambert-Eaton myasthenic syndrome (LEMS) is an antibody-mediated disorder of the neuromuscular junction that is most commonly diagnosed in association with small cell lung carcinoma (SCLC). Small cell lung carcinoma is histologically similar to the aggressive cutaneous neuroendocrine malignancy Merkel cell carcinoma (MCC). We provide a full report and longitudinal clinical follow-up of a case of LEMS occurring with MCC. We also review the literature on paraneoplastic syndromes associated with MCC and other nonpulmonary small cell carcinomas.
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