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Non-Invasive Biomarkers for Celiac Disease
Alka Singh1, Atreyi Pramanik2, Pragyan Acharya3
1Department of Gastroenterology and Human Nutrition; All India Institute of Medical Sciences, New Delhi-110029, India. singhalka34@gmail.com.
Journal of Clinical Medicine
|June 26, 2019
Summary
Celiac disease diagnosis relies on antibodies and biopsies, but new biomarkers are needed for easier screening, diagnosis, and monitoring of gluten-free diet adherence. Research explores advanced techniques like transcriptomics for better celiac disease management.
Area of Science:
- Gastroenterology
- Immunology
- Biomarker Discovery
Background:
- Celiac disease is a prevalent global autoimmune disorder.
- Current treatment involves strict gluten-free diet (GFD) adherence.
- Existing diagnostic methods have limitations, necessitating improved biomarkers.
Purpose of the Study:
- To review current biomarkers for celiac disease screening, diagnosis, and monitoring.
- To discuss the pros and cons of available diagnostic methods.
- To summarize emerging biomarkers for improved celiac disease management.
Main Methods:
- Review of existing literature on celiac disease biomarkers.
- Analysis of diagnostic criteria including antibody testing and villous abnormalities.
- Exploration of novel biomarker discovery using transcriptomics, proteomics, and metabolomics.
Main Results:
- No single gold standard test exists for celiac disease diagnosis.
- Anti-tissue transglutaminase antibody titers can predict enteropathy, potentially avoiding biopsies.
- Emerging biomarkers show promise for screening, diagnosis, and monitoring GFD adherence.
Conclusions:
- Improved biomarkers are crucial for effective celiac disease screening, diagnosis, and monitoring.
- Advanced omics technologies are key to discovering new biomarkers.
- Future research focuses on non-invasive methods for celiac disease management.
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