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A Bioinformatics Pipeline for Investigating Molecular Evolution and Gene Expression using RNA-seq

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Evolution Shapes the Gene Expression Response to Oxidative Stress.

Rima Siauciunaite¹, Nicholas S Foulkes², Viola Calabrò³

¹Institute of Toxicology and Genetics, Karlsruhe Institute of Technology, Hermann-von-Helmholtz-Platz 1, 76344 Eggenstein-Leopoldshafen, Germany. rima.siauciunaite@kit.edu.

International Journal of Molecular Sciences

|June 26, 2019

Summary

Reactive oxygen species (ROS) are vital for cell function but can damage DNA. Organisms evolved circadian clocks to manage oxidative stress, showing evolutionary plasticity in ROS response mechanisms.

Keywords:

D-box DNA damage ROS Spalax cavefish evolution light

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Measurements of Physiological Stress Responses in C. Elegans

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Published on: May 21, 2020

Area of Science:

Cellular Physiology
Evolutionary Biology
Molecular Biology

Background:

Reactive oxygen species (ROS) are crucial for cell signaling and gene expression.
Oxidative stress from ROS can damage DNA and other macromolecules.
Circadian clocks may have evolved to anticipate and manage daily ROS fluctuations.

Purpose of the Study:

To review recent findings on species-specific gene expression responses to ROS.
To explore the evolutionary conservation and adaptation of ROS response mechanisms.
To highlight the plasticity in molecular mechanisms responding to oxidative stress.

Main Methods:

Review of recent scientific literature.
Analysis of gene expression data across diverse organisms.
Comparative evolutionary studies of ROS response pathways.

Main Results:

Significant species-specific differences in gene expression responses to ROS were identified.
Evidence suggests that ROS response mechanisms are not highly conserved across species.
Diverse organisms exhibit unique adaptations to manage oxidative stress.

Conclusions:

The molecular mechanisms responding to oxidative stress demonstrate significant evolutionary plasticity.
Understanding these mechanisms requires studying diverse organisms, not just model systems.
Adaptations to ROS are ancient but exhibit considerable variation shaped by environmental conditions.