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Gene therapy is a technique where a gene is inserted into a person’s cells to prevent or treat a serious disease. The added gene may be a healthy version of the gene that is mutated in the patient, or it could be a different gene that inactivates or compensates for the patient’s disease-causing gene. For example, in patients with severe combined immunodeficiency (SCID) due to a mutation in the gene for the enzyme adenosine deaminase, a functioning version of the gene can be...
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Psychodynamic therapies emphasize the exploration of unconscious processes and early childhood experiences as fundamental contributors to psychological difficulties. These therapies, deeply rooted in Freud's psychoanalytic theory, aim to uncover and resolve unconscious conflicts, granting individuals insights that promote emotional and behavioral healing. Contemporary psychodynamic approaches have evolved, integrating a broader range of influences and methodologies while still valuing the...
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Intra- and Inter-Tumor <i>BRAF</i> Heterogeneity in Acral Melanoma: An Immunohistochemical Analysis.

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Adjuvant Therapy for Melanoma.

Maiko Wada-Ohno1, Takamichi Ito2, Masutaka Furue2

  • 1Department of Dermatology, Graduate School of Medical Sciences, Kyushu University, -1-1 Maidashi, Higashi-ku, Fukuoka, 812-8582, Japan. maiko@dermatol.med.kyushu-u.ac.jp.

Current Treatment Options in Oncology
|June 26, 2019
PubMed
Summary
This summary is machine-generated.

Adjuvant therapy for melanoma improves survival after surgery. Anti-PD-1 antibodies are recommended for patients without BRAF mutations, while dabrafenib and trametinib combination is suitable for those with BRAF mutations.

Keywords:
Adjuvant therapyImmune therapyMelanomaNeoadjuvant therapyRadiotherapyTargeted therapy

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Area of Science:

  • Oncology
  • Dermatology
  • Immunotherapy

Background:

  • Malignant melanoma incidence is rising globally.
  • Surgery is the primary treatment for resectable melanoma.
  • Adjuvant therapy is increasingly approved for advanced stages (III and IV) post-resection.

Purpose of the Study:

  • To review clinical trials on adjuvant therapies for melanoma.
  • To identify optimal adjuvant treatment strategies for improved survival.
  • To guide therapeutic planning and clinical endpoints in adjuvant therapy.

Main Methods:

  • Review of clinical trials involving radiotherapy, systemic immune therapies, molecular-targeted therapies, and neoadjuvant therapies.
  • Analysis of treatment efficacy and toxicity profiles.
  • Evaluation of patient-specific factors like BRAF mutation status.

Main Results:

  • Interferon-α2b use may be limited to specific cases in resource-limited settings.
  • Ipilimumab is not recommended as first-line therapy due to toxicity and lower efficacy.
  • Anti-programmed death-1 (PD-1) antibody is suitable for BRAF-wildtype melanoma.
  • Combination of dabrafenib and trametinib is a viable option for BRAF-mutated melanoma.

Conclusions:

  • Optimal adjuvant therapy selection is crucial for individual melanoma patients.
  • BRAF mutation status significantly influences treatment choice.
  • Establishing appropriate therapeutic planning and endpoints is essential for the standard of care.