Related Experiment Video
Updated: Jan 23, 2026

How to Obtain Reliable Visual Event-related Potentials in Newborns
Published on: October 24, 2019
Changes in Activities of Somatovisceral Systems in Newborn Rats under Conditions of Nicotinic Cholinoreceptor
1I. M. Sechenov Institute of Evolutional Physiology and Biochemistry, the Russian Academy of Sciences, St. Petersburg, Russia. sizonvladimir@yandex.ru.
Abstract:
Relationship between the residual effects of disorders in the cholinergic system and the activities of the cardiac, respiratory, and somatomotor systems of 1- and 16-day-old rats were studied. Experiments were carried out on intact conscious rats before and after drug injection (nicotinic cholinoreceptor blocker benzohexonium). In order to increase the level of cholinoreactive structure activation, acetylcholinesterase inhibition by eserine was carried out. Injection of benzohexonium caused rarefaction of HR, respiration rate, and a decrease of motor activity parameters in rats of both age groups. Injection of eserine after cholinolytic premedication led to further rarefaction of the respiration rate and HR. The reaction of the somatosensory system to changed level of cholinoreactive structure activation was age-specific. Motor activity increased in 1-day-old rats and was depressed significantly in 16-day-old ones.
Related Concept Videos
Structure-Activity Relationships and Drug Design
SAR studies the intricate relationship between a drug's chemical structure and biological activity. It focuses on understanding how modifications to a drug's structure can influence...
Co-activators and Co-repressors
Activation Energy
Cholinergic Antagonists: Chemistry and Structure-Activity Relationship
Adrenergic Agonists: Chemistry and Structure-Activity Relationship
Aromatic ring substitutions: Substituting the aromatic ring with –OH groups at positions 3 and 4 yields catecholamines (e.g., epinephrine), which have a high affinity for adrenoceptors. Hydrogen bonding between –OH groups and receptors enhances adrenergic activity.
Separation of...
Local Anesthetics: Chemistry and Structure-Activity Relationship

