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Updated: Jan 23, 2026

Restraint to Induce Stress in Mice and Rats
Published on: December 6, 2024
State of Colon Microbiota in Rats during Chronic Restraint Stress and Selank Treatment
A Yu Mukhina1, O A Medvedeva1, M V Svishcheva1
1Kursk State Medical University, Ministry of Health of the Russian Federation, Kursk, Russia.
Abstract:
We studied the effects of Selank on intestinal microbiota in Wistar male rats subjected to chronic restraint stress. Selank was injected intraperitoneally in doses of 80, 250 and 750 μg/kg 15 min before stress exposure. Chronic restraint stress led to a decrease in the content of obligate microflora, while the content of opportunistic microorganisms increased. Selank restored intestinal microbiota presumably via central (neurotropic) and peripheral (immunotropic) mechanisms.
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