Modeling of multiple planning target volumes for head and neck treatments in knowledge-based treatment planning

The purpose of this study is to develop an accurate and reliable dose volume histogram (DVH) prediction method for external beam radiation therapy plans with multiple planning target volumes (PTVs).

We present a novel DVH prediction workflow, including new features and a modeling methodology, that makes better use of multiple PTVs: (a) We propose a generalized feature to characterize the geometric relationship of organ-at-risk (OARs) with respect to two or more PTVs with different prescribed dose levels; (b) We incorporate a novel data augmentation method to improve the data distribution in the feature space; (c) A similarity metric that leverages such information is subsequently used to select a subset of similar cases from the training dataset for model building; (d) Finally, a DVH prediction model is trained with these selected cases. To evaluate this new modeling workflow, we used 120 head and neck (HN) cases to tune the model, and used a separate dataset consisting of 148 cases for validation. The proposed model has been compared with the conventional knowledge-based model in terms of model prediction accuracy, which was measured by the root mean squared error (RMSE) between the predicted DVHs and the actual clinical plan DVHs. Furthermore, 25 randomly selected plans were replanned guided by the proposed model and evaluated against clinical plans using clinical evaluation criteria.

The proposed modeling workflow significantly improved DVH prediction accuracy for brainstem (P < 0.001), cord (P < 0.001), larynx (P = 0.004), mandible (P < 0.001), oral cavity (P = 0.011), parotid (P < 0.001) and pharynx (P = 0.001). Cases replanned with the guidance of the proposed model spared OARs significantly better by clinical evaluation criteria. The replanned cases showed a 15% increase in the number of satisfied criteria, compared with clinical plans.

The proposed modeling workflow generates DVH predictions with improved accuracy and robustness when multiple PTVs exist in a plan. It has demonstrated that the improvement in the DVH prediction model translates into better plan quality in knowledge-based planning.