Nabilone administration in refractory chronic diarrhea: a case series
Lanfranco Pellesi1, Maria Chiara Verga2, Nicola De Maria2
1Medical Toxicology and Headache Center, University of Modena and Reggio Emilia, via del Pozzo 71, 41124, Modena, Italy. lanfranco.pellesi@gmail.com.
BMC Gastroenterology
|June 27, 2019
Summary
Cannabinoids, specifically CB1-receptor agonists like nabilone, show promise in treating chronic diarrhea. This study found nabilone improved symptoms and quality of life in patients with refractory diarrhea.
Area of Science:
- Gastroenterology
- Pharmacology
- Endocannabinoid System Research
Background:
- The endocannabinoid system regulates gut homeostasis, motility, and secretion.
- Cannabinoids were historically used for gastrointestinal symptoms like diarrhea.
- Cannabinoids may offer therapeutic potential for gastrointestinal disorders.
Observation:
- A retrospective analysis of six patients with refractory chronic diarrhea treated with a CB1-receptor agonist (nabilone).
- Treatment duration ranged from April 2008 to July 2016.
- Nabilone was administered orally.
Findings:
- Oral nabilone significantly improved diarrheal symptoms and led to weight gain in most patients.
- Therapeutic benefits persisted for at least three months post-treatment.
- One patient discontinued nabilone due to fatigue and confusion, which resolved after cessation.
Implications:
- CB1 receptor agonists warrant further investigation for refractory chronic diarrhea.
- Cannabinoid-based therapies may enhance the quality of life for selected patients with chronic gastrointestinal conditions.
- Nabilone demonstrates a reasonable safety profile for managing refractory diarrhea.
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