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The Association Between Polypharmacy and Physical Function in Older Adults: a Systematic Review
Andreas Katsimpris1, Jacob Linseisen2,3, Christa Meisinger2,3
1Ludwig-Maximilians-Universität München, UNIKA-T Augsburg, Augsburg, Germany. Andreas.Katsimpris@campus.lmu.de.
Journal of General Internal Medicine
|June 27, 2019
Summary
Reduced physical function and polypharmacy (PPha) are strongly linked in older adults. Better physical function is associated with less PPha, and PPha is linked to poorer physical function, highlighting a bidirectional relationship.
Area of Science:
- Gerontology
- Geriatric Medicine
- Public Health
Background:
- Aging populations face challenges with reduced physical function and polypharmacy (PPha).
- Existing research indicates a potential link between physical function and PPha in older adults.
- Demographic trends predict an increase in these age-related issues.
Purpose of the Study:
- To systematically review and analyze the relationship between physical function and PPha in older adults.
- To summarize recent scientific evidence on the bidirectional association between these factors.
- To inform clinicians about the interplay between physical function and medication use in the elderly.
Main Methods:
- Conducted a systematic literature search of MEDLINE and Embase up to October 2018.
- Included English-language observational studies and trials examining PPha and physical function in older adults.
- Two independent investigators extracted data and assessed study quality.
Main Results:
- Eighteen observational studies met the inclusion criteria.
- Most studies (8/9) found better physical function associated with lower risk of PPha.
- Most studies (9/10) indicated PPha is associated with reduced physical function.
Conclusions:
- A strong bidirectional association exists between physical function and PPha in older adults.
- Clinicians should recognize this significant relationship in geriatric care.
- Variability in definitions and analysis methods were noted limitations.
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