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Personal identity is the deeply felt sense of self that individuals cultivate over time, intricately woven from intrinsic qualities they consider essential to their existence—qualities such as morality, intelligence, and friendliness. These attributes serve as vital internal benchmarks, guiding individuals in evaluating whether their actions resonate with their true selves.When personal identity takes center stage in one's life, individuals often emphasize their distinctiveness,...
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ARBoR: an identity and security solution for clinical reporting.

Eric Venner1, Mullai Murugan1, Walker Hale1

  • 1Human Genome Sequencing Center, Baylor College of Medicine, Houston, Texas, USA.

Journal of the American Medical Informatics Association : JAMIA
|June 27, 2019
PubMed
Summary
This summary is machine-generated.

We developed ARBoR (Authenticated Resources in a Hashed Block Registry) to track the authenticity and lineage of clinical genome sequencing reports. This system provides a tamper-proof method for managing versioned reports, ensuring data integrity.

Keywords:
clinical genomicsgenetic report

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Area of Science:

  • Genomic Medicine
  • Bioinformatics
  • Clinical Informatics

Background:

  • Clinical genome sequencing laboratories generate reports with test results, often in PDF or paper format.
  • These reports are frequently updated due to evolving variant interpretations and clinical data.
  • Ensuring the authenticity and tracking the lineage of these versioned reports is crucial for patient care.

Purpose of the Study:

  • To develop a robust system for tracking the authenticity and lineage of versioned clinical genome sequencing reports.
  • To provide a secure and verifiable method for managing report updates, regardless of their distribution format (PDF, paper, or structured data).

Main Methods:

  • Developed ARBoR (Authenticated Resources in a Hashed Block Registry), an application utilizing cryptographically signed hash blocks.
  • Stored report hashes in an electronic ledger file that is replicated across multiple clients.
  • Implemented ARBoR within a clinical laboratory setting, including the Human Genome Sequencing Center Clinical Laboratory.

Main Results:

  • Successfully implemented ARBoR for clinical reporting, initially as part of the NIH's eMERGE project.
  • Tracked over 15,205 versioned clinical reports to date using the ARBoR system.
  • Demonstrated ARBoR's capability to provide a simple and tamper-proof mechanism for managing complex report update histories.

Conclusions:

  • ARBoR offers a reliable solution for maintaining the integrity and traceability of clinical genome sequencing reports.
  • The system effectively addresses the challenges associated with version control and authenticity verification in clinical genomics.
  • ARBoR enhances trust and security in the dissemination of critical genetic testing results.