Future Perspective of Diabetic Animal Models

Area of Science:

• * Endocrinology and immunology research.
• * Pre-clinical research and drug discovery.

Background:

• * Diabetic animal models are vital for understanding disease pathogenesis, genetic factors, and microbiota influences.
• * Many immunotherapies successful in animals fail in human clinical trials due to model limitations.
• * Inconsistent animal models lead to low success rates for drug candidates in clinical trials.

Purpose of the Study:

• * To evaluate the significance of existing diabetic animal models.
• * To rank popular models based on PubMed literature.
• * To propose future directions for developing advanced diabetic models.

Main Methods:

• * Literature review and analysis of published data on PubMed.
• * Selection and ranking of six prominent diabetic animal models.
• * Discussion of future concepts for next-generation diabetic models.

Main Results:

• * Six key diabetic animal models were identified and ranked: BioBreeding rat, LEW IDDM rat, Nonobese Diabetic (NOD) mouse, STZ RAT, LEPR Mouse, and Zucker Diabetic Fatty (ZDF) rat.
• * The review highlights the strengths and limitations of these models in pre-clinical research.
• * A vision for a 21st-century diabetic model, including the
• one mouse-one human
• concept and organs-on-chips, was presented.

Conclusions:

• * Existing animal models have contributed significantly but require validation for consistency.
• * Ranking models based on literature aids in selecting appropriate tools for research.
• * Future models should aim for improved human relevance, potentially integrating advanced technologies.